ArticleFrontiers in physiology2022
The Functions and Mechanisms of Low-Level Laser Therapy in Tendon Repair (Review).
Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Deep Learning-Based OCT Segmentation for Stiffness Quantification in Evaluating Low-Level Laser Therapy for Wound Healing.Journal of biophotonics · 2026Trial
- Efficacy of Adjunctive Photobiomodulation in Patellofemoral Pain Syndrome: A Systematic Review and Meta-Analysis.Archives of rehabilitation research and clinical translation · 2026Review
- The Immediate, Short-Term and Long-Term Effects of Photobiomodulation on Chronic Post-Surgical Pain After Tympanomastoidectomy Surgery.Journal of lasers in medical sciences · 2026Article
- Convergent Regenerative Strategies in PM&R for Musculoskeletal and Hair Restoration: Integration of PRP, Exosomes, and Physical Modalities.Archives of internal medicine research · 2026Article
- The Effectiveness of Photobiomodulation Therapy on Pain and Function in Patients with Patellofemoral Pain Syndrome-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Tailored Rehabilitation Program and Dynamic Ultrasonography After Surgical Repair of Bilateral Simultaneous Quadriceps Tendon Rupture in a Patient Affected by Gout: A Case Report.Healthcare (Basel, Switzerland) · 2025Article
- Histopathology Findings of Low-Level Laser Therapy Effectiveness on Achilles Tendon Repair in Rabbit Model.Veterinary medicine and science · 2025Article
- The combination of hyaluronic acids and collagen boosts human Achilles tendon-derived cell escape from inflammation and matrix remodeling in vitro.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- The Application of Photobiomodulation on Mesenchymal Stem Cells and its Potential Use for Tenocyte Differentiation.Current stem cell research & therapy · 2025Review
- Comparative Effectiveness of Digitally and Conventionally Fabricated Occlusal Splints with Low-Power Laser Therapy in Treating Temporomandibular Disorders.Journal of lasers in medical sciences · 2025Article
- Experimental evaluation of the healing potential ofFrontiers in bioengineering and biotechnology · 2025Article
- In-vitro study on type I collagen synthesis in low-level laser therapy on the early ligament fibroblasts' healing process.Lasers in medical science · 2024Article
- Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives-A Review.Veterinary sciences · 2024Review
- Osteogenic potential of apical papilla stem cells mediated by platelet-rich fibrin and low-level laser.Odontology · 2024Article
- miRNAs contributing to the repair of tendon injury.Cell and tissue research · 2023Review
- The Influence of Different Modes of Exercise on Healthy and Injured Tendons.Stem cells international · 2022Review
- The EGF Motif With CXDXXXXYXCXC Sequence Suppresses Fibrosis in a Mouse Skin Wound Model.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tendon injury is a common disease of the musculoskeletal system, accounting for roughly 30%-40% of sports system disorder injuries. In recent years, its incidence is increasing. Many studies have shown that low-level laser therapy (LLLT) has a significant effect on tendon repair by firstly activating cytochrome C oxidase and thus carrying out the photon absorption process, secondly acting in all the three phases of tendon repair, and finally improving tendon recovery. The repair mechanisms of LLLT are different in the three phases of tendon repair. In the inflammatory phase, LLLT mainly activates a large number of VEGF and promotes angiogenesis under hypoxia. During the proliferation phase, LLLT increases the amount of collagen type III by promoting the proliferation of fibroblasts. Throughout the remodeling phase, LLLT mainly activates M2 macrophages and downregulates inflammatory factors, thus reducing inflammatory responses. However, it should also be noted that in the final phase of tendon repair, the use of LLLT causes excessive upregulation of some growth factors, which will lead to tendon fibrosis. In summary, we need to further investigate the functions and mechanisms of LLLT in the treatment of tendon injury and to clarify the nature of LLLT for the treatment of diverse tendon injury diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.