Evidence map›Paper›PMID 35242021›Full record

ArticleFrontiers in neuroinformatics2022

The Brain Observatory Storage Service and Database (BossDB): A Cloud-Native Approach for Petascale Neuroscience Discovery.

Robert Hider, Dean Kleissas, Timothy Gion, Daniel Xenes, Jordan Matelsky, Derek Pryor, Luis Rodriguez, Erik C Johnson, William Gray-Roncal, Brock Wester

Abstract read
In one paragraph

Article in Frontiers in neuroinformatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. RAEM: random-access electron microscopy for revisitable 3D imaging.bioRxiv : the preprint server for biology · 2026
    Article
  3. Physical contact reveals a hidden layer of cortical architecture.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. PyReconstruct: A fully open-source, collaborative successor to Reconstruct.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. FAIR African brain data: challenges and opportunities.Frontiers in neuroinformatics · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. ArXiv · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Robert HiderResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Dean KleissasResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Timothy GionResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Daniel XenesResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Jordan MatelskyResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Derek PryorResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Luis RodriguezResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Erik C JohnsonResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
William Gray-RoncalResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Brock WesterResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.

Funding

Boss: A cloud-based data archive for electron microscopy and x-ray microtomographyR24MH114785 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BROCK A. WESTER · 2018 to 2026
$6.9M
Big-Data Electron-microscopy for Novel Community Hypotheses: Measuring And Retrieving Knowledge (BENCHMARK)R01MH126684 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GRAY RONCAL, WILLIAM R · 2021 to 2022
$1.3M
SABER: Scalable Analytics for Brain Exploration Research using X-Ray Microtomography and Electron MicroscopyR24MH114799 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GRAY RONCAL, WILLIAM R · 2017 to 2019
$1.2M
NIMH NIH HHS R01 MH126684NIMH NIH HHS R24 MH114785NIMH NIH HHS R24 MH114799
6 · The paper itself

Abstract

Technological advances in imaging and data acquisition are leading to the development of petabyte-scale neuroscience image datasets. These large-scale volumetric datasets pose unique challenges since analyses often span the entire volume, requiring a unified platform to access it. In this paper, we describe the Brain Observatory Storage Service and Database (BossDB), a cloud-based solution for storing and accessing petascale image datasets. BossDB provides support for data ingest, storage, visualization, and sharing through a RESTful Application Programming Interface (API). A key feature is the scalable indexing of spatial data and automatic and manual annotations to facilitate data discovery. Our project is open source and can be easily and cost effectively used for a variety of modalities and applications, and has effectively worked with datasets over a petabyte in size.

Indexed as

cloudconnectomedataelectron microscopyimagingsoftwarestorageX-ray

Identifiers

PMID35242021
PMCPMC8885591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.