ArticleInternational journal of nephrology and renovascular disease2022
Disease-Associated Systemic Complications in Childhood Nephrotic Syndrome: A Systematic Review.
Article in International journal of nephrology and renovascular disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Incidence and risk factors for acute kidney injury in children with nephrotic syndrome: a meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Combined Fibrinogen and Urinary α1-Microglobulin as Predictors of Respiratory Tract Infection in Children with Nephrotic Syndrome.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Dental caries prevention as a modifiable precipitating factor of nephrotic syndrome relapse in children: an insight into simple-novel management.International urology and nephrology · 2025Article
- Knowledge, Attitude, and Practice of Nurses in Preventing Complications in Patients with Nephrotic Syndrome: A Cross-Sectional Study.Therapeutics and clinical risk management · 2025Article
- Nutritional management of pediatric nephrotic syndrome regarding oxidative stress and antioxidant balance.Frontiers in immunology · 2025Review
- Clinical analysis of sirolimus therapy in children with refractory nephrotic syndrome.Renal failure · 2024Article
- Association between hypothyroidism and nephrotic syndrome: a bidirectional two-sample Mendelian randomization analysis.Renal failure · 2024Article
- Prevalence and associated factors of infection in children with nephrotic syndrome aged 2-18 years in the northwest and east Amhara region, Ethiopia: a multi-center cross-sectional retrospective study.BMC public health · 2024Article
- Complications Related to Childhood Idiopathic Nephrotic Syndrome, Its Treatment and the Associated Risks in Patients.Cureus · 2023Article
- Analysis of the association of NPHS2 and ACTN4 genes polymorphism with nephrotic syndrome in Egyptian children.Molecular biology reports · 2023Article
- Mesenteric Arterial Thrombosis Revealing Relapse of Nephrotic Syndrome in Young Women.International medical case reports journal · 2023Article
- Metabolomics Profiling of Nephrotic Syndrome towards Biomarker Discovery.International journal of molecular sciences · 2022Article
- Multiple Venous and Pulmonary Artery Thrombosis as a Presenting Complaint of Nephrotic Syndrome-Case Report and Challenges in Management.Vascular health and risk management · 2022Article
- Factors Affecting Neurocognitive Function in Children with Chronic Kidney Disease: A Systematic Review.International journal of nephrology and renovascular disease · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNephrotic syndrome (NS) is one of the most common childhood kidney diseases. During the active phase, the disease pathogenesis affects various biological functions linked to loss of proteins negatively, which can result in systemic complications. Complications of childhood NS are divided into two categories: disease-associated complications and drug-associated complications. However, complications in pediatric patients with NS, especially disease-associated complications are still limited. Although reported in the literature, information is not comprehensive and needs to be updated. This study aimed to systematically assess systemic complications in children with NS, especially disease-associated complications, to better understand how they impact outcomes.
methodsWe conducted a systematic search of several databases: BioMed Central Pediatrics, PubMed, Google Scholar, the National Library of Medicine, Cochrane Library, CINAHL/EBSCO,
resultsEleven articles concerning complications in childhood NS were analyzed. Systemic disease-associated complications in covered were cardiovascular complications, infections, thyroid-hormone complication, kidney complications, and oral health complications.
conclusionNS is marked by heavy proteinuria, hypoalbuminemia, edema, and hyperlipidemia, which can result in systemic disease-associated complications. Cardiovascular complications, infections, thyroid-hormone complications, kidney complications, and oral health complications are the main systemic complications in childhood NS. It is essential that health-care providers prevent these complications for proper maintenance of patients' health.
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