ArticleNature genetics2022
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease.
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In one paragraph
Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 2 pooled it
19.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 2 syntheses or guidelines pooled it, 176 citations in OpenAlex.
- Canadian COVID-19 host genetics cohort replicates known severity associations.PLoS genetics · 2024Pooled it
- Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects.Nature genetics · 2022Pooled it
- Systems genetics analysis reveals immune mediators of coronavirus disease severity in mice.Genetics · 2026Article
- Integrated Inflammatory, Thrombo-Inflammatory, Redox and Soluble IFNAR2 Profiling During Hospitalization for COVID-19: An Exploratory Observational Cohort Study.Journal of clinical medicine · 2026Article
- Association of ABO/Rh Blood Groups and ABO Gene VariantsViruses · 2026Article
- Identification and functional characterization of regulatory variants in DPP9 associated with COVID-19 severity.Genome medicine · 2026Article
- Molecular systems, human noncoding sequence variants, and blood pressure.Physiological reviews · 2026Review
- A Unique Patient Stratification Method Combined with a Machine Learning Approach Identifies Novel Genetic Susceptibility and Protective Factors for Severe COVID-19 in a Hungarian Population.International journal of molecular sciences · 2026Article
- Comparative GWAS using global and Indian Reference Panels reveals non-coding drivers of COVID-19 severity and mortality.PLoS neglected tropical diseases · 2026Article
- Article
- Hybrid feature selection with novel deep learning model for COVID-19 risk prediction.Scientific reports · 2026Article
- Multi-omics identifies oxidative stress, prothrombotic pathways, and lactoperoxidase variants as key factors in COVID-19 severity.EBioMedicine · 2026Article
- Viral Prognosis Using Proteomics.Advances in experimental medicine and biology · 2026Review
- The seven enigmas of SARS-CoV-2: from the past to the future.Journal of human immunity · 2025Article
- Revealing associations between exposure to cyanobacteria toxins and COVID-19 outcomes in Colorado.medRxiv : the preprint server for health sciences · 2025Article
- Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions.Nature communications · 2025Article
- Differential Circulating Proteomic Responses Associated with Ancestry during Severe COVID-19 Infection.Journal of proteome research · 2025Article
- Role of ACE1, ACE2, and CCR5-Δ32 Polymorphisms in the Transmission of SARS-CoV-2 to Intimate Contacts.Biology · 2025Article
- Genetic Analysis and Predictive Modeling of COVID-19 Severity in a Hospital-Based Patient Cohort.Biomolecules · 2025Article
- Genetic proxies for clinical traits are associated with increased risk of severe COVID-19.Scientific reports · 2025Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
60 authors at 4 institutions in 2 countries.
Julie E Horowitz *Regeneron Genetics Center, Tarrytown, NY, USA.
Jack A Kosmicki *Regeneron Genetics Center, Tarrytown, NY, USA.
Amy Damask *Regeneron Genetics Center, Tarrytown, NY, USA.
Deepika SharmaRegeneron Genetics Center, Tarrytown, NY, USA.
Genevieve H L RobertsAncestryDNA, Lehi, UT, USA.ORCID http://orcid.org/0000-0003-4007-0700
Anne E JusticeGeisinger, Danville, PA, USA.
Nilanjana BanerjeeRegeneron Genetics Center, Tarrytown, NY, USA.
Marie V CoignetAncestryDNA, Lehi, UT, USA.
Ashish YadavRegeneron Genetics Center, Tarrytown, NY, USA.
Joseph B LeaderGeisinger, Danville, PA, USA.ORCID http://orcid.org/0000-0002-4101-5423
Anthony MarckettaRegeneron Genetics Center, Tarrytown, NY, USA.
Danny S ParkAncestryDNA, Lehi, UT, USA.
Rouel LancheRegeneron Genetics Center, Tarrytown, NY, USA.
Evan MaxwellRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-7325-7531
Spencer C KnightAncestryDNA, Lehi, UT, USA.
Xiaodong BaiRegeneron Genetics Center, Tarrytown, NY, USA.
Harendra GuturuAncestryDNA, Lehi, UT, USA.
Dylan SunRegeneron Genetics Center, Tarrytown, NY, USA.
Asher BaltzellAncestryDNA, Lehi, UT, USA.
Fabricio S P KuryRegeneron Genetics Center, Tarrytown, NY, USA.
Joshua D BackmanRegeneron Genetics Center, Tarrytown, NY, USA.
Ahna R GirshickAncestryDNA, Lehi, UT, USA.
Colm O'DushlaineRegeneron Genetics Center, Tarrytown, NY, USA.
Shannon R McCurdyAncestryDNA, Lehi, UT, USA.
Raghavendran ParthaAncestryDNA, Lehi, UT, USA.
Adam J MansfieldRegeneron Genetics Center, Tarrytown, NY, USA.
David A TurissiniAncestryDNA, Lehi, UT, USA.
Alexander H LiRegeneron Genetics Center, Tarrytown, NY, USA.
Miao ZhangAncestryDNA, Lehi, UT, USA.
Joelle MbatchouRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-2245-3743
Kyoko WatanabeRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-3303-8860
Lauren GurskiRegeneron Genetics Center, Tarrytown, NY, USA.
Shane E McCarthyRegeneron Genetics Center, Tarrytown, NY, USA.
Hyun M KangRegeneron Genetics Center, Tarrytown, NY, USA.
Lee DobbynRegeneron Genetics Center, Tarrytown, NY, USA.
Eli StahlRegeneron Genetics Center, Tarrytown, NY, USA.
Anurag VermaDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Giorgio SirugoDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Regeneron Genetics Center
Marylyn D RitchieDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1208-1720
Marcus JonesRegeneron Genetics Center, Tarrytown, NY, USA.
Suganthi BalasubramanianRegeneron Genetics Center, Tarrytown, NY, USA.
Katherine SiminovitchRegeneron Genetics Center, Tarrytown, NY, USA.
William J SalernoRegeneron Genetics Center, Tarrytown, NY, USA.
Alan R ShuldinerRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-9921-4305
Daniel J RaderDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9245-9876
Tooraj MirshahiGeisinger, Danville, PA, USA.ORCID http://orcid.org/0000-0002-0754-3820
Adam E LockeRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-6227-198X
Jonathan MarchiniRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0003-0610-8322
John D OvertonRegeneron Genetics Center, Tarrytown, NY, USA.
David J CareyGeisinger, Danville, PA, USA.
Lukas HabeggerRegeneron Genetics Center, Tarrytown, NY, USA.
Michael N CantorRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-1074-1203
Kristin A RandAncestryDNA, Lehi, UT, USA.
Eurie L HongAncestryDNA, Lehi, UT, USA.
Jeffrey G ReidRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-8645-4713
Catherine A BallAncestryDNA, Lehi, UT, USA.
Aris BarasRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-6830-3396
Gonçalo R AbecasisRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0003-1509-1825
Manuel A R FerreiraRegeneron Genetics Center, Tarrytown, NY, USA. manuel.ferreira@regeneron.com.ORCID http://orcid.org/0000-0001-9059-1825
Regeneron (United States) · USGeisinger Medical Center · USUniversity of Pennsylvania · USGenomics (United Kingdom) · GB
Funding
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MNCATS NIH HHS UL1 TR001878
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human host cells via angiotensin-converting enzyme 2 (ACE2) and causes coronavirus disease 2019 (COVID-19). Here, through a genome-wide association study, we identify a variant (rs190509934, minor allele frequency 0.2-2%) that downregulates ACE2 expression by 37% (P = 2.7 × 10
Indexed as
COVID-19Angiotensin-Converting Enzyme 2Genome-Wide Association StudyHumansRisk FactorsSARS-CoV-2Angiotensin-Converting Enzyme 2
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