ArticleMolecular psychiatry2022
Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits.
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Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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25citing papers in PubMed, 2 pooled it
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.Nature genetics · 2024Pooled it
- Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records.Molecular psychiatry · 2022Pooled it
- Towards scalable biomarker discovery in posttraumatic stress disorder: triangulating genomic and phenotypic evidence from a health system biobank.Molecular psychiatry · 2026Article
- The Rostral Ventrolateral Medulla Input to Central Amygdala Regulates Anxiety-Like Behaviors in Mice for Chronic Light Exposure.CNS neuroscience & therapeutics · 2026Article
- Integrating multi-atlas neuroimaging data for robust biomarker identification in neuropsychiatric disorders.Frontiers in psychiatry · 2026Article
- Integration of Metabolomic and Brain Imaging Data Highlights Pleiotropy Among Posttraumatic Stress Disorder, Glycoprotein Acetyls, and Pallidum Structure.Biological psychiatry global open science · 2025Article
- Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses.Nature communications · 2025Article
- Implications of gene × environment interactions in post-traumatic stress disorder risk and treatment.The Journal of clinical investigation · 2025Review
- Shared genetic architecture and bidirectional clinical risks within the psycho-metabolic nexus.EBioMedicine · 2025Article
- Identifying molecular signatures of post-traumatic stress disorder vulnerability and progression in a longitudinal study: a study protocol.Frontiers in psychiatry · 2025Article
- A multi-omics Mendelian randomization study identifies new therapeutic targets for alcohol use disorder and problem drinking.Nature human behaviour · 2025Article
- [A study on post-traumatic stress disorder classification based on multi-atlas multi-kernel graph convolutional network].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- Identifying Genetically Inferred Effects Linking Posttraumatic Stress Disorder to Women's Health, Lipid Disorders, and Malaria Medications.The American journal of psychiatry · 2024Article
- Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study.Nature genetics · 2024Article
- Genetics of posttraumatic stress disorder and cardiovascular conditions using Life's Essential 8, Electronic Health Records, and Heart Imaging.medRxiv : the preprint server for health sciences · 2024Article
- Effects of sex and gender on the etiologies and presentation of select internalizing psychopathologies.Translational psychiatry · 2024Review
- The ROSMAP project: aging and neurodegenerative diseases through omic sciences.Frontiers in neuroinformatics · 2024Review
- Role of Artificial Intelligence in Drug Discovery and Target Identification in Cancer.Current drug delivery · 2024Review
- Independent effects of posttraumatic stress disorder diagnosis and metabolic syndrome status on prefrontal cortical thickness and subcortical gray matter volumes.Dialogues in clinical neuroscience · 2023Article
- Three-dimensional mitochondria reconstructions of murine cardiac muscle changes in size across aging.American journal of physiology. Heart and circulatory physiology · 2023Article
Corrections and comments
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Authors and funding
22 authors.
Gita A PathakDepartment of Psychiatry, Yale School of Medicine, West Haven, CT, 06516, USA.
Kritika SinghDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-9872-7942
Frank R WendtDepartment of Psychiatry, Yale School of Medicine, West Haven, CT, 06516, USA.ORCID http://orcid.org/0000-0002-2108-6822
Tyne W FlemingDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Cassie OverstreetDepartment of Psychiatry, Yale School of Medicine, West Haven, CT, 06516, USA.
Dora KollerDepartment of Psychiatry, Yale School of Medicine, West Haven, CT, 06516, USA.ORCID http://orcid.org/0000-0002-0415-0466
Daniel S TyleeDepartment of Psychiatry, Yale School of Medicine, West Haven, CT, 06516, USA.ORCID http://orcid.org/0000-0002-7579-6096
Flavio De AngelisDepartment of Psychiatry, Yale School of Medicine, West Haven, CT, 06516, USA.
Brenda Cabrera MendozaDepartment of Psychiatry, Yale School of Medicine, West Haven, CT, 06516, USA.
Daniel F LeveyDepartment of Psychiatry, Yale School of Medicine, West Haven, CT, 06516, USA.ORCID http://orcid.org/0000-0001-8431-9569
Karestan C KoenenDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
John H KrystalDepartment of Psychiatry, Yale School of Medicine, West Haven, CT, 06516, USA.ORCID http://orcid.org/0000-0001-6952-1726
Robert H PietrzakDepartment of Psychiatry, Yale School of Medicine, West Haven, CT, 06516, USA.
Christopher O' DonellCardiology Section, Department of Medicine, VA Boston Healthcare System, Boston, MA, USA.
J Michael GazianoDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Guido FalconeDivision of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale School of Medicine, 15 York Street, LLCI 1004D, Box 208018, New Haven, CT, 06520, USA.
Murray B SteinVA San Diego Healthcare System, Psychiatry Service, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-9564-2871
Joel GelernterDepartment of Psychiatry, Yale School of Medicine, West Haven, CT, 06516, USA.ORCID http://orcid.org/0000-0002-4067-1859
Bogdan PasaniucDepartments of Computational Medicine, Human Genetics, Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Nicholas MancusoDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9352-5927
Lea K DavisDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5143-2282
Renato PolimantiDepartment of Psychiatry, Yale School of Medicine, West Haven, CT, 06516, USA. renato.polimanti@yale.edu.ORCID http://orcid.org/0000-0003-0745-6046
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MPharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4MUnderstanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH, RODEN, DAN M · 2015 to 2019
$13.0MTraining and Mentoring CoreU54MD010722 · NIMHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILKINS, CONSUELO HOPKINS · 2016 to 2020
$11.9MThe Genetic Epemiology of Multiple SclerosisR01NS032830 · NINDS · VANDERBILT UNIVERSITY · PI HAINES, JONATHAN L · 1995 to 2010
$8.9MEpidemiologic Architecture for Genes Linked to Environment (EAGLE)U01HG004798 · NHGRI · VANDERBILT UNIVERSITY · PI CRAWFORD, DANA C · 2008 to 2013
$8.8MRESEARCH TRAINING - BIOLOGICAL SCIENCEST32MH014276 · NIMH · YALE UNIVERSITY · PI Marina R Picciotto · 1985 to 2026
$7.2MVESPA: Vanderbilt Electronic Systems for Pharmacogenomic AssessmentRC2GM092618 · NIGMS · VANDERBILT UNIVERSITY · PI DENNY, JOSHUA C., RODEN, DAN M · 2009 to 2010
$6.4MVanderbilt Genome Electronic Records ProjectU01HG006378 · NHGRI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2011 to 2014
$4.0MDiscovering Biology for Neuropsychiatric Diseases Through Omics Studies on ComorbiditiesR01MH113362 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COX, NANCY J, KNAPIK, ELA W · 2017 to 2021
$3.9MMedical Research Council MC_PC_17228Medical Research Council MC_QA137853NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHGRI NIH HHS T32 HG008341NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006378NHLBI NIH HHS U19 HL065962NICHD NIH HHS R01 HD074711NIDA NIH HHS R33 DA047527NIDCD NIH HHS R21 DC018098NIGMS NIH HHS P50 GM115305NIGMS NIH HHS RC2 GM092618NIH HHS S10 OD017985NIMHD NIH HHS U54 MD010722NIMH NIH HHS F32 MH122058NIMH NIH HHS R01 MH113362NIMH NIH HHS R56 MH120736NIMH NIH HHS T32 MH014276NINDS NIH HHS R01 NS032830
Abstract
Posttraumatic stress disorder (PTSD) is a psychiatric disorder that may arise in response to severe traumatic event and is diagnosed based on three main symptom clusters (reexperiencing, avoidance, and hyperarousal) per the Diagnostic Manual of Mental Disorders (version DSM-IV-TR). In this study, we characterized the biological heterogeneity of PTSD symptom clusters by performing a multi-omics investigation integrating genetically regulated gene, splicing, and protein expression in dorsolateral prefrontal cortex tissue within a sample of US veterans enrolled in the Million Veteran Program (N
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Stress Disorders, Post-TraumaticVeteransDiagnostic and Statistical Manual of Mental DisordersHumansPhenotypeSyndrome
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