Evidence map›Paper›PMID 35241769›Full record

ArticleActa pharmacologica Sinica2022

Platelet CFTR inhibition enhances arterial thrombosis via increasing intracellular Cl

Han-Yan Yang, Chao Zhang, Liang Hu, Chang Liu, Ni Pan, Mei Li, Hui Han, Yi Zhou, Jie Li, Li-Yan Zhao and 13 more

Open access · bronzeAbstract read
In one paragraph

Article in Acta pharmacologica Sinica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 8 institutions in 2 countries.

Han-Yan Yang *Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Chao Zhang *Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Liang Hu *Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Chang LiuDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Ni PanDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Mei LiVIP Healthcare Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.
Hui HanDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Yi ZhouGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Jie LiDepartment of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.
Li-Yan ZhaoDepartment of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.
Yao-Sheng LiuDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Bing-Zheng LuoGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Xiong-Qing HuangDepartment of Anesthesiology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Xiao-Fei LvDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Zi-Cheng LiDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Jun LiDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Zhi-Hong LiDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Ruo-Mei WangSchool of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, 510006, China.
Li WangDivision of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Yong-Yuan GuanDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Can-Zhao LiuDepartment of Cardiovascular Medicine, Translational Medicine Research Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China. liucanzhao0521@163.com.
Bin ZhangGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China. drbinzhang@gdph.org.cn.
Guan-Lei WangDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. wangglei@mail.sysu.edu.cn.
Sun Yat-sen University · CNGuangdong Provincial People's Hospital · CNGuangdong Academy of Medical Sciences · CNShanghai University of Traditional Chinese Medicine · CNThe First Affiliated Hospital, Sun Yat-sen University · CNThird Affiliated Hospital of Sun Yat-sen University · CNUniversity of California, San Diego · USZhujiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelet hyperactivity is essential for thrombus formation in coronary artery diseases (CAD). Dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) in patients with cystic fibrosis elevates intracellular Cl

Indexed as

Cystic Fibrosis Transmembrane Conductance RegulatorImmediate-Early ProteinsThrombosisAdenosine TriphosphateAnimalsBlood PlateletsChloridesMiceMice, KnockoutNF-kappa BProtein Serine-Threonine KinasesSerum-Glucocorticoid Regulated KinasesSignal TransductionAdenosine TriphosphateChloridesCystic Fibrosis Transmembrane Conductance RegulatorImmediate-Early ProteinsNF-kappa BProtein Serine-Threonine KinasesSerum-Glucocorticoid Regulated KinasesCFTRcoronary artery diseaseintracellular chlorideplateletSGK1thrombosis

Identifiers

PMID35241769
PMCPMC9525590
OpenAlexW4221011693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.