ArticleRegional anesthesia and pain medicine2022
Association of opioid exposure before surgery with opioid consumption after surgery.
Article in Regional anesthesia and pain medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07221786 (A Pilot Study of the Feasibility of Preoperative Opioid Tapering Before Spine Surgery Using Cognitive Behavioral Therapy and Measuring Postoperative Outcomes), which is not on this map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study of the Feasibility of Preoperative Opioid Tapering Before Spine Surgery Using Cognitive Behavioral Therapy and Measuring Postoperative Outcomes
Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- What predicts postoperative opioid prescribing and consumption? A statewide analysis of surgical quality registry data.Pain medicine (Malden, Mass.) · 2026Article
- Impact of preoperative opioid exposure on cost of care and workplace productivity loss after elective surgery.Regional anesthesia and pain medicine · 2026Article
- Opioid use in postoperative pain management of pediatric appendectomy patients in Japan.Journal of anesthesia · 2025Article
- Postoperative Opioid Consumption After Discharge: An Update From the Michigan Surgical Quality Collaborative Registry.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Perioperative Opioid-Related Harms: Opportunities to Minimize Risk.Seminars in plastic surgery · 2024Review
- Patient Experiences and Clinical Outcomes in a Multidisciplinary Perioperative Transitional Pain Service.Journal of personalized medicine · 2023Article
- Association of Reported Nonsteroidal Anti-Inflammatory Drug (NSAID) Adverse Drug Reactions With Opioid Prescribing After Total Joint Arthroplasty.The journal of allergy and clinical immunology. In practice · 2023Article
- The development of a safe opioid use agreement for surgical care using a modified Delphi method.PloS one · 2023Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo determine the effect of prescription opioid use in the year before surgery on opioid consumption after surgery.
backgroundRecently developed postoperative opioid prescribing guidelines rely on data from opioid-naïve patients. However, opioid use in the USA is common, and the impact of prior opioid exposure on the consumption of opioids after surgery is unclear.
methodsPopulation-based cohort study of 26,001 adults 18 years of age and older who underwent one of nine elective general or gynecologic surgical procedures between January 1, 2017 and October 31, 2019, with prospectively collected patient-reported data from the Michigan Surgical Quality Collaborative (MSQC) linked to state prescription drug monitoring program at 70 MSQC-participating hospitals on 30-day patient-reported opioid consumption in oral morphine equivalents (OME) (primary outcome).
resultsCompared with opioid-naïve participants, opioid-exposed participants (26% of sample) consumed more prescription opioids after surgery (adjusted OME difference 12, 95% CI 10 to 14). Greater opioid exposure was associated with higher postoperative consumption in a dose-dependent manner, with chronic users reporting the greatest consumption (additional OMEs 32, 95% CI 21 to 42). However, for eight of nine procedures, 90% of opioid-exposed participants consumed ≤150 OMEs. Among those receiving perioperative prescriptions, opioid-exposed participants had higher likelihood of refill (adjusted OR 4.7, 95% CI 4.4 to 5.1), number of refills (adjusted incidence rate ratio 4.0, 95% CI 3.7 to 4.3), and average refill amount (adjusted OME difference 333, 95% CI 292 to 374)).
conclusionsPreoperative opioid use is associated with small increases in patient-reported opioid consumption after surgery for most patients, though greater differences exist for patients with chronic use. For most patients with preoperative opioid exposure, existing guidelines may meet their postoperative needs. However, guidelines may need tailoring for patients with chronic use, and providers should anticipate a higher likelihood of postoperative refills for all opioid-exposed patients.
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