ArticleIn vivo (Athens, Greece)
Development of New Mouse Breast Cancer Model of Local Bone Metastasis and Verification Using Bisphosphonates.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Primary Bone Tumors and Breast Cancer-Induced Bone Metastases: In Vivo Animal Models and New Alternative Approaches.Biomedicines · 2024Review
- Development of a New Focal Mouse Model of Bone Metastasis in Renal Cell Carcinoma.In vivo (Athens, Greece)Article
- Analysis of Risedronate Analog on Extraction Socket Healing in Mice.In vivo (Athens, Greece)Article
- Teriparatide Does Not Exacerbate Bone Metastases in Breast Cancer Bone Metastasis Model.In vivo (Athens, Greece)Article
- Effect of Zoledronic Acid Administration Timing on Metastatic Bone Tumors.In vivo (Athens, Greece)Article
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Authors and funding
7 authors.
Funding
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Abstract
BACKGROUND/
aimLocal tumor injection models require complicated procedures. The purpose was to establish a simple local bone metastasis model using normal mice, and to study the usefulness of the model with bisphosphonates (BP). MATERIALS AND
methodsThis study used a versatile C57BL/6 mouse model and E0771 cells. Tumor cells were injected into the right femur. Mice were divided into groups depending on the concentration of cells injected and the use of BP or not. The degree of bone destruction between the different conditions was compared using micro-computed tomography (μCT).
resultsBone destruction was confirmed in four mice in the high-concentration group at 3 weeks, and in all other mice at 4 and 6 weeks. At 6 weeks post-injection, bone destruction was significantly suppressed in the BP group (p<0.05).
conclusionWe created a breast cancer mouse model of local bone metastasis. Zoledronate showed the same usefulness as in previous models. It may be an effective model for evaluating treatments for bone metastasis.
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