Evidence map›Paper›PMID 35241515›Full record

ArticleIn vivo (Athens, Greece)

Induction of DNA Damage in Mouse Colorectum by Administration of Colibactin-producing

Takumi Narita, Yuta Tsunematsu, Noriyuki Miyoshi, Masami Komiya, Takahiro Hamoya, Gen Fujii, Yuko Yoshikawa, Michio Sato, Masanobu Kawanishi, Haruhiko Sugimura and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Takumi NaritaDepartment of Molecular-Targeting Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yuta TsunematsuDepartment of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Noriyuki MiyoshiSchool of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
Masami KomiyaEpidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
Takahiro HamoyaDepartment of Molecular-Targeting Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Gen FujiiCentral Radioisotope Division, National Cancer Center Research Institute, Tokyo, Japan.
Yuko YoshikawaSchool of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Musashino, Japan.
Michio SatoDepartment of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Masanobu KawanishiGraduate School of Science and Radiation Research Center, Osaka Prefecture University, Sakai, Japan.
Haruhiko SugimuraDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Yuji IwashitaDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Yukari TotsukaLaboratory of Environmental Toxicology and Carcinogenesis, School of Pharmacy, Nihon University, Funabashi, Japan.
Masaru TerasakiSchool of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Kanazawa, Japan.
Kenji WatanabeDepartment of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Keiji WakabayashiGraduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan.
Michihiro MutohDepartment of Molecular-Targeting Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; mimutoh@koto.kpu-m.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimAmong colorectal cancer-associated intestinal microbiota, colibactin-producing (clb MATERIALS AND

methodsFive-week-old female Balb/c mice were divided in an untreated group, a group treated with clb

resultsTreatment with clb

conclusionE. coli-50 induced DNA damage in the mouse rectum, possibly by direct interaction between clb

Indexed as

Colorectal NeoplasmsEscherichia coli InfectionsAnimalsDNA DamageEscherichia coliFemaleHumansMicePeptidesPolyketidesRatscolibactinPeptidesPolyketidesColibactincolorectal cancerDNA damagemouseγH2AX-positive cells

Identifiers

PMID35241515
PMCPMC8931918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.