ArticleSleep health2022
Self-reported sleep characteristics and risk for incident vertebral and hip fracture in women.
Article in Sleep health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Association of healthy sleep pattern with the risk of falls and fractures among individuals with cardiovascular disease: a UK Biobank study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- High prevalence of vertebral fractures associated with apnea-hypopnea index in patients with recent diagnosis of obstructive sleep apnea.BMC musculoskeletal disorders · 2025Article
- Association between sleep duration and hip fracture risk among the older adults: a cross-sectional study based on the NHANES.BMC musculoskeletal disorders · 2025Article
- Risk factors for osteoporosis in elderly patients with type 2 diabetes: A protocol for systematic review and meta-analysis.PloS one · 2025Article
- Sleep and risk of hip fracture and falls among middle-aged and older Chinese.Scientific reports · 2024Article
- Analysis of Changes in Sleep Quality and Patterns after Hip Fracture Using Real Evidence of Artificial Intelligence Linked (REAL) Hip Cohort Data.Medicina (Kaunas, Lithuania) · 2023Article
- Association of Self-Reported Sleep Characteristics and Hip Fracture: Observational and Mendelian Randomization Studies.Healthcare (Basel, Switzerland) · 2023Article
- Association between changes in depressive symptoms and hip fracture among middle-aged and older Chinese individuals: a prospective cohort study.BMC geriatrics · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo examine the relationships between self-reported sleep characteristics and risk of incident vertebral fracture and hip fracture in women.
designLongitudinal cohort study.
settingNurses' Health Studies (NHS: 2002-2014, NHSII: 2001-2015).
participantsTotal 122,254 female registered nurses (46,129 NHS, 76,125 NHSII) without prior history of fracture. EXPOSURE: Sleep was characterized by 4 sleep-related domains-sleep duration, sleep difficulty, snoring, and excessive daytime sleepiness-assessed by self-reported questionnaires. OUTCOMES: Self-reports of vertebral fracture were confirmed by medical record review and hip fracture was assessed by biennial questionnaires.
resultsOver 12-14 years of follow-up, 569 incident vertebral fracture cases (408 in NHS, 161 in NHSII) and 1,881 hip fracture cases (1,490 in NHS, 391 in NHSII) were documented. In the pooled analysis, the multivariable-adjusted HR (95% CI) for vertebral fracture was 1.20 (0.86, 1.66) for sleep duration ≤5 hours vs. 7 hours and 0.82 (0.60, 1.12) for ≥9 vs. 7 hours; 1.63 (0.93, 2.87) for sleep difficulties all-the-time vs. none/little-of-the-time (p-trend = 0.005); 1.47 (1.05, 2.05) for snoring every night/week vs. never/occasionally (p-trend = 0.03), and 2.20 (1.49, 3.25) for excessive daytime sleepiness daily vs. never (p-trend < 0.001). In contrast, associations were not observed with hip fracture risk.
conclusionPoorer sleep characteristics were associated with risk of vertebral fracture. Our study highlights the importance of multiple dimensions of sleep in the development of vertebral fractures. Further research is warranted to understand the role of sleep in bone health that may differ by fracture site, as well as sleep interventions that may reduce the risk of fracture.
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