Evidence map›Paper›PMID 35241224›Full record

ArticleJournal of the American College of Cardiology2022

Recovery With Temporary Mechanical Circulatory Support While Waitlisted for Heart Transplantation.

Veli K Topkara, Gabriel T Sayer, Kevin J Clerkin, Omar Wever-Pinzon, Koji Takeda, Hiroo Takayama, Craig H Selzman, Yoshifumi Naka, Daniel Burkhoff, Josef Stehlik and 4 more

Abstract read
In one paragraph

Article in Journal of the American College of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Heart Transplantation.Journal of clinical medicine · 2024
    Review
  14. Review
  15. Review
  16. UNOS policy change benefits high-priority patients without harming those at low priority.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Veli K TopkaraDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA. Electronic address: vt2113@cumc.columbia.edu.
Gabriel T SayerDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Kevin J ClerkinDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Omar Wever-PinzonDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, Utah, USA.
Koji TakedaDivision of Cardiothoracic Surgery, Department of Surgery, Columbia University Irving Medical Center, New York, New York, USA.
Hiroo TakayamaDivision of Cardiothoracic Surgery, Department of Surgery, Columbia University Irving Medical Center, New York, New York, USA.
Craig H SelzmanDivision of Cardiothoracic Surgery, Department of Surgery, University of Utah, Salt Lake City, Utah, USA.
Yoshifumi NakaDivision of Cardiothoracic Surgery, Department of Surgery, Columbia University Irving Medical Center, New York, New York, USA.
Daniel BurkhoffDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Josef StehlikDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, Utah, USA.
Maryjane A FarrDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
James C FangDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, Utah, USA.
Nir UrielDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Stavros G DrakosDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, Utah, USA.

Funding

Clinical and Metabolic Signature of Recovered Myocardium in Human Heart FailureR01HL135121 · NHLBI · UNIVERSITY OF UTAH · PI DRAKOS, STAVROS GEORGE · 2017 to 2021
$1.9M
Cellular Remodeling in Heart Failure and after LVAD UnloadingR01HL132067 · NHLBI · UNIVERSITY OF UTAH · PI DRAKOS, STAVROS GEORGE, SACHSE, FRANK BERND · 2017 to 2020
$1.5M
Role of DNA methylation in cardiac failure and recoveryK23HL150322 · NHLBI · UNIVERSITY OF UTAH · PI WEVER-PINZON, OMAR ENRIQUE · 2020 to 2024
$994k
Identifying Novel Diagnostics and Mechanisms for Cardiac Allograft VasculopathyK23HL148528 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLERKIN, KEVIN J · 2020 to 2024
$852k
Defining the Role of lnc-TECRL in Maladaptive Cardiac RemodelingK08HL146964 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TOPKARA, VELI KEMAL · 2019 to 2022
$671k
Understanding Myocardial Recovery in Diabetes and Heart FailureI01CX002291 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI DRAKOS, STAVROS GEORGE · 2021 to 2025
–
CSRD VA I01 CX002291NHLBI NIH HHS K08 HL146964NHLBI NIH HHS K23 HL148528NHLBI NIH HHS K23 HL150322NHLBI NIH HHS R01 HL132067NHLBI NIH HHS R01 HL135121
6 · The paper itself

Abstract

backgroundThe 2018 U.S. heart allocation system offers an accelerated pathway for heart transplantation to the most urgent patients.

objectivesThis study sought to determine whether the new allocation system resulted in lower likelihood of candidate recovery.

methodsAdult patients waitlisted for heart transplantation with temporary mechanical circulatory support at the time of initial listing between 2010 and 2020 in the United Network for Organ Sharing registry were included. Competing events of heart transplantation, waitlist death or delisting for deteriorating condition, and delisting for improved condition (candidate recovery) were analyzed in the new vs old heart allocation system.

resultsA total of 688 patients were waitlisted with venoarterial extracorporeal membrane oxygenation or a surgical nondischargeable biventricular assist device (status 1 or old 1A). Overall, 2,237 patients were waitlisted with an intra-aortic balloon pump, a percutaneous left ventricular assist device (LVAD), or a surgical nondischargeable LVAD (status 2 or old 1A). Patients waitlisted with venoarterial extracorporeal membrane oxygenation or a nondischargeable biventricular assist device had significantly shorter median waitlist times (5 vs 31 days), higher incidence for cardiac transplantation (81.5% vs 43.0%), and lower incidence of candidate recovery (1.5% vs 7.9%) in the new vs old heart allocation system (all P < 0.05). Patients waitlisted with an intra-aortic balloon pump or percutaneous or a nondischargeable LVAD also had significantly shorter median waitlist times (8 vs 35 days), higher incidence of transplantation (88.9% vs 64.9%), and lower incidence of candidate recovery (0.2% vs 1.6%) in the new vs old heart allocation system (all P < 0.05).

conclusionsCurrent practice of the new allocation system may not offer select temporary mechanical circulatory support patients the opportunity and adequate time to recover to the point of waitlist removal. Further research will determine which patients would benefit from urgent transplantation vs recovery strategy.

Indexed as

Extracorporeal Membrane OxygenationHeart-Assist DevicesHeart FailureHeart TransplantationAdultHumansIntra-Aortic Balloon PumpingRetrospective StudiesTreatment Outcomecandidate recoveryguidelineheart transplantation

Identifiers

PMID35241224
PMCPMC8928585

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.