Evidence map›Paper›PMID 35241218›Full record

ArticleJournal of the American College of Cardiology2022

Variability in Coronary Artery Disease Testing for Patients With New-Onset Heart Failure.

Jimmy Zheng, Paul A Heidenreich, Shun Kohsaka, William F Fearon, Alexander T Sandhu

Abstract read
In one paragraph

Article in Journal of the American College of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Cardiometabolic Dysregulation and Heart Failure.Reviews in cardiovascular medicine · 2025
    Review
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Article
  15. Revascularisation for Ischaemic Cardiomyopathy.Interventional cardiology (London, England) · 2023
    Review
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jimmy ZhengStanford University School of Medicine, Stanford, California, USA. Electronic address: jimmyz1@stanford.edu.
Paul A HeidenreichDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California, USA; Department of Medicine, Palo Alto VA Veteran's Affairs Hospitals, Palo Alto, California, USA. Electronic address: https://twitter.com/paheidenreich.
Shun KohsakaDepartment of Cardiology, Keio University School of Medicine, Tokyo, Japan.
William F FearonDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California, USA; Department of Medicine, Palo Alto VA Veteran's Affairs Hospitals, Palo Alto, California, USA. Electronic address: https://twitter.com/wfearonmd.
Alexander T SandhuDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California, USA. Electronic address: https://twitter.com/ATSandhu.

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
The Effect of Value-based Payment on Heart Failure Quality of Care (Value-HF)K23HL151672 · NHLBI · STANFORD UNIVERSITY · PI SANDHU, ALEXANDER · 2020 to 2024
$854k
NCATS NIH HHS UL1 TR001085NCATS NIH HHS UL1 TR003142NHLBI NIH HHS K23 HL151672
6 · The paper itself

Abstract

backgroundCoronary artery disease (CAD) is the most common cause of new-onset heart failure (HF). Although guidelines recommend ischemic evaluation in this population, testing has historically been underutilized.

objectivesThis study aimed to identify contemporary trends in CAD testing for patients with new-onset HF, particularly after publication of the STICHES (Surgical Treatment for Ischemic Heart Failure Extension Study), and to characterize geographic and clinician-level variability in testing patterns.

methodsWe determined the proportion of patients with incident HF who received CAD testing from 2004 to 2019 using an administrative claims database covering commercial insurance and Medicare. We identified demographic and clinical predictors of CAD testing during the 90 days before and after initial diagnosis. Patients were grouped by their county of residence to assess national variation. Patients were then linked to their primary care physician and/or cardiologist to evaluate variation across clinicians.

resultsAmong 558,322 patients with new-onset HF, 34.8% underwent CAD testing and 9.3% underwent revascularization. After multivariable adjustment, patients who underwent CAD testing were more likely to be younger, male, diagnosed in an acute care setting, and have systolic dysfunction or recent cardiogenic shock. Incidence of CAD testing remained flat without significant change post-STICHES. Covariate-adjusted testing rates varied from 20% to 45% across counties. The likelihood of testing was higher among patients co-managed by a cardiologist (adjusted OR: 5.12; 95% CI: 4.98-5.27) but varied substantially across cardiologists (IQR: 50.9%-62.4%).

conclusionsMost patients with new-onset HF across inpatient and outpatient settings did not receive timely testing for CAD. Substantial variability in testing persists across regions and clinicians.

Indexed as

Coronary Artery DiseaseHeart FailureAgedHumansMaleMedicareOutpatientsUnited Statesdisparityinvasiveischemic CADrevascularizationSTICHESstress testing

Identifiers

PMID35241218
PMCPMC9031351

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.