Evidence map›Paper›PMID 35240875›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue.

Marc Briquet, Anne-Bérengère Rocher, Maxime Alessandri, Nadia Rosenberg, Haissa de Castro Abrantes, Joel Wellbourne-Wood, Céline Schmuziger, Vanessa Ginet, Julien Puyal, Etienne Pralong and 3 more

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In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 51 citations in OpenAlex.

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  6. Tanycyte-derived lactate activates astrocytic HCAR1 to modulate glutamatergic signaling and POMC neuron excitability.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  20. Oncology research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Marc BriquetDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Anne-Bérengère RocherDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Maxime AlessandriDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Nadia RosenbergDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Haissa de Castro AbrantesDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Joel Wellbourne-WoodDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Céline SchmuzigerDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Vanessa GinetDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Julien PuyalDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Etienne PralongDepartment of Neurosurgery Service, University Hospital of Lausanne and Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland.
Roy Thomas DanielDepartment of Neurosurgery Service, University Hospital of Lausanne and Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland.
Stefan OffermannsMax Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Jean-Yves ChattonDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
University of Lausanne · CHMax Planck Institute for Heart and Lung Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactate can be used by neurons as an energy substrate to support their activity. Evidence suggests that lactate also acts on a metabotropic receptor called HCAR1, first described in the adipose tissue. Whether HCAR1 also modulates neuronal circuits remains unclear. In this study, using qRT-PCR, we show that HCAR1 is present in the human brain of epileptic patients who underwent resective surgery. In brain slices from these patients, pharmacological HCAR1 activation using a non-metabolized agonist decreased the frequency of both spontaneous neuronal Ca

Indexed as

Dentate GyrusEpilepsyNeuronsReceptors, G-Protein-CoupledAnimalsBrainExcitatory Postsynaptic PotentialsHumansLactic AcidMiceRatsHCAR1 protein, humanHcar1 protein, mouseLactic AcidReceptors, G-Protein-CoupledDentate gyruselectrophysiologyepilepsyHCA1 receptorhuman brain slices

Identifiers

PMID35240875
PMCPMC9441721
OpenAlexW4214853178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.