Evidence map›Paper›PMID 35240311›Full record

ArticleHeart rhythm2022

Reduced motion external defibrillation: Reduced subject motion with equivalent defibrillation efficiency validated in swine.

Ehud J Schmidt, Hassan Elahi, Eric S Meyer, Ryan Baumgaertner, Luca Neri, Ronald D Berger, Harikrishna Tandri, David W Hunter, Steven P Cohen, Matt T Oberdier and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ehud J SchmidtDepartment of Medicine (Cardiology), Johns Hopkins University, Baltimore, Maryland. Electronic address: eschmi17@jhu.edu.
Hassan ElahiDepartment of Medicine (Cardiology), Johns Hopkins University, Baltimore, Maryland.
Eric S MeyerDepartment of Medicine (Cardiology), Johns Hopkins University, Baltimore, Maryland.
Ryan BaumgaertnerDepartment of Medicine (Cardiology), Johns Hopkins University, Baltimore, Maryland.
Luca NeriDepartment of Medicine (Cardiology), Johns Hopkins University, Baltimore, Maryland.
Ronald D BergerDivision of Pain Medicine, Johns Hopkins University, Baltimore, Maryland.
Harikrishna TandriDepartment of Medicine (Cardiology), Johns Hopkins University, Baltimore, Maryland.
David W HunterDepartment of Medicine (Cardiology), Johns Hopkins University, Baltimore, Maryland.
Steven P CohenDivision of Pain Medicine, Johns Hopkins University, Baltimore, Maryland.
Matt T OberdierDepartment of Medicine (Cardiology), Johns Hopkins University, Baltimore, Maryland.
Henry R HalperinDepartment of Medicine (Cardiology), Johns Hopkins University, Baltimore, Maryland.
Johns Hopkins University · US

Funding

Improved Targeting and Assessment of Electrophysiology InterventionR01HL094610 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HALPERIN, HENRY R · 2009 to 2018
$15.5M
Atrial fibrillation ablation assessment and guidance using native-contrast T1 weighted MRIR01HL157259 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KOLANDAIVELU, ARAVINDAN · 2021 to 2025
$3.9M
Intraprocedure Model-Guided ElectrophysiologyR01EB022011 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI HALPERIN, HENRY R · 2018 to 2021
$2.3M
NHLBI NIH HHS R01 HL094610NHLBI NIH HHS R01 HL157259NIBIB NIH HHS R01 EB022011
6 · The paper itself

Abstract

backgroundExternal defibrillators are used for arrhythmia cardioversion and for defibrillating during cardiac arrest. During defibrillation, short-duration biphasic pulses cause intense motion due to rapid chest-wall muscle contraction. A reduced motion external defibrillator (RMD) was constructed by integrating a commercial defibrillator with a Tetanizing-waveform generator. A long-duration, low-amplitude, tetanizing waveform slowly stimulated the chest musculature before the biphasic pulse, reducing muscle contraction during the shock.

objectiveThe purpose of this study was to evaluate RMD defibrillation in swine for subject motion during defibrillation pulses and for defibrillation effectiveness. RMD defibrillation can reduce the duration of arrhythmia ablation therapy or simplify cardioversion procedures.

methodsThe tetanizing unit delivered a triangular 1-kHz pulse of 0.25- to 2.0-second duration and 10- to 100-V peak amplitude, subsequently triggering the conventional defibrillator to output standard 1- to 200-J energy biphasic pulses at the next R wave. Forward limb motion was evaluated by measuring peak acceleration and limb work during RMD (tetanizing + biphasic) or biphasic pulse-only waveforms at 10

resultsTwo forward-limb acceleration peaks occurred during both the tetanizing waveform and biphasic pulse, indicating rapid and slower nociceptic (pain sensation) nerve fiber activation. Optimal RMD tetanizing parameters (25-35 V, 0.25- to 0.75-second duration), relative to biphasic pulse-only defibrillations, resulted in 74% ± 10% smaller peak accelerations and 85% ± 10% reduced limb work. DFT energies were identical when comparing RMD to biphasic pulse-only defibrillations.

conclusionRelative to conventional defibrillations, RMD defibrillations maintain rhythm restoration efficiency with drastically reduced subject motion.

Indexed as

Electric CountershockHeart ArrestAnimalsArrhythmias, CardiacDefibrillatorsSwineVentricular FibrillationCardioversionDefibrillation effectivenessDefibrillation motionSudden cardiac arrestVentricular tachycardia

Identifiers

PMID35240311
PMCPMC9250595
OpenAlexW4214741153

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.