Evidence map›Paper›PMID 35240026›Full record

ArticleAnimal bioscience2022

Long non-coding RNAs in Sus scrofa ileum under starvation stress.

Shu Wang, Yi Jia Ma, Yong Shi Li, Xu Sheng Ge, Chang Lu, Chun Bo Cai, Yang Yang, Yan Zhao, Guo Ming Liang, Xiao Hong Guo and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal bioscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Shu WangDepartment of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi Province 030801, China.
Yi Jia MaDepartment of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi Province 030801, China.
Yong Shi LiDepartment of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi Province 030801, China.
Xu Sheng GeInner Mongolia Mengniu Dairy(GROUP) CO., LTD, Shengle Economic Zone, Helingeer Hohhot, Inner Mongolia 011500, China.
Chang LuDepartment of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi Province 030801, China.
Chun Bo CaiDepartment of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi Province 030801, China.
Yang YangDepartment of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi Province 030801, China.
Yan ZhaoDepartment of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi Province 030801, China.
Guo Ming LiangDepartment of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi Province 030801, China.
Xiao Hong GuoDepartment of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi Province 030801, China.
Guo Qing CaoDepartment of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi Province 030801, China.
Bu Gao LiDepartment of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi Province 030801, China.
Peng Fei GaoDepartment of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi Province 030801, China.
Shanxi Agricultural University · CNInner Mongolia Electric Power (China) · CN

Funding

Fund for Shanxi 1331 Project 2017key research projects in agriculture of the Shanxi Province 201803D221022-1National Natural Science Foundation of China 31872336Program for Sanjin Scholar 2016Program for Sanjin Scholar 2017Shanxi Agriculture University Science & Technology Innovation Fund 2017YJ07
6 · The paper itself

Abstract

objectiveIn this study, we aimed to identify long non-coding RNAs (lncRNAs) that play important roles in starvation stress, analyze their functions, and discover potential molecular targets to alleviate starvation stress to provide a theoretical reference for subsequent in-depth research.

methodsWe generated a piglet starvation stress animal model. Nine Yorkshire weaned piglets were randomly divided into a long-term starvation stress group (starved for 72 h), short-term starvation stress group (starved for 48 h), and the control group. LncRNA libraries were constructed using high-throughput sequencing of piglet ileums.

resultsWe obtained 11,792 lncRNAs, among which, 2,500 lncRNAs were novel. In total, 509 differentially expressed (DE)lncRNAs were identified in this study. Target genes of DElncRNAs were predicted via cis and trans interactions, and functional and pathway analyses were performed. Gene ontology functions and Kyoto encyclopedia of genes and genomes analysis revealed that lncRNA-targeted genes mainly participated in metabolic pathways, cellular processes, immune system processes, digestive systems, and transport activities. To reveal the mechanism underlying starvation stress, the interaction network between lncRNAs and their targets was constructed based on 26 DElncRNAs and 72 DEmRNAs. We performed an interaction network analysis of 121 DElncRNA-DEmRNA pairs with a Pearson correlation coefficient greater than 0.99.

conclusionWe found that MSTRG.19894.13, MSTRG.16726.3, and MSTRG.12176.1 might play important roles in starvation stress. This study not only generated a library of enriched lncRNAs in piglets, but its outcomes also provide a strong foundation to screen key lncRNAs involved in starvation stress and a reference for subsequent in-depth research.

Indexed as

Co-expression NetworkLncRNAPigsStarvation Stress

Identifiers

PMID35240026
PMCPMC9271390
OpenAlexW4214862978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.