Evidence map›Paper›PMID 35239457›Full record

ReviewAutophagy2022

The role of ATG16L2 in autophagy and disease.

Laurence Don Wai Luu, Nadeem O Kaakoush, Natalia Castaño-Rodríguez

Open access · greenAbstract readReview
In one paragraph

Review in Autophagy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Autophagy · 2026
    Article
  3. Article
  4. Review
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  7. Article
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  11. Review
  12. Review
  13. IntracellularFrontiers in microbiology · 2024
    Article
  14. Article
  15. Review
  16. Article
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  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Laurence Don Wai LuuSchool of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, New South Wales, Australia.
Nadeem O KaakoushSchool of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0003-4017-1077
Natalia Castaño-RodríguezSchool of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0001-8819-8872
UNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macroautophagy/autophagy, a fundamental cell process for nutrient recycling and defense against pathogens (termed xenophagy), is crucial to human health. ATG16L2 (autophagy related 16 like 2) is an autophagic protein and a paralog of ATG16L1. Both proteins are implicated in similar diseases such as cancer and other chronic diseases; however, most autophagy studies to date have primarily focused on the function of ATG16L1, with ATG16L2 remaining uncharacterized and understudied. Overexpression of ATG16L2 has been reported in various cancers including colorectal, gastric, and prostate carcinomas, whereas altered methylation of

Indexed as

AutophagyAutophagy-Related ProteinsHumansInflammatory Bowel DiseasesNeoplasmsNeurodegenerative DiseasesAutophagy-Related ProteinsATG16L1ATG16L2autophagycancermacroautophagyxenophagy

Identifiers

PMID35239457
PMCPMC9629082
OpenAlexW4214936436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.