Evidence map›Paper›PMID 35239434›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Dual-function AzuCR RNA modulates carbon metabolism.

Medha Raina, Jordan J Aoyama, Shantanu Bhatt, Brian J Paul, Aixia Zhang, Taylor B Updegrove, Juan Miranda-Ríos, Gisela Storz

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 30 citations in OpenAlex.

  1. Bacterial stress responses lower mRNA-protein level correlations.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Bacterial small regulatory RNAs.Nature reviews. Microbiology · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Gene regulation inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Large Roles of Small Proteins.Annual review of microbiology · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. Two for one: regulatory RNAs that encode small proteins.Trends in biochemical sciences · 2023
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Medha RainaDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892-5430.
Jordan J AoyamaDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892-5430.
Shantanu BhattDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892-5430.
Brian J PaulDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892-5430.
Aixia ZhangDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892-5430.
Taylor B UpdegroveLaboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892.
Juan Miranda-RíosDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892-5430.
Gisela StorzDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892-5430.ORCID 0000-0001-6698-1241
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Cancer Institute · US

Funding

Small Regulatory RNAsZIAHD001608 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STORZ, GISELA · 2009 to 2025
$16.9M
Small Regulatory ProteinsZIAHD008855 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STORZ, GISELA · 2009 to 2025
$16.3M
Intramural NIH HHS ZIA HD001608Intramural NIH HHS ZIA HD008855
6 · The paper itself

Abstract

SignificanceWhile most small, regulatory RNAs are thought to be "noncoding," a few have been found to also encode a small protein. Here we describe a 164-nucleotide RNA that encodes a 28-amino acid, amphipathic protein, which interacts with aerobic glycerol-3-phosphate dehydrogenase and increases dehydrogenase activity but also base pairs with two mRNAs to reduce expression. The coding and base-pairing sequences overlap, and the two regulatory functions compete.

Indexed as

CarbonCulture MediaEscherichia coliEscherichia coli ProteinsGalactoseGlycerolGlycerolphosphate DehydrogenaseMembrane ProteinsProtein BiosynthesisRNA, BacterialRNA, MessengerCarbonCulture MediaEscherichia coli ProteinsGalactoseGlycerolGlycerolphosphate DehydrogenaseMembrane ProteinsRNA, BacterialRNA, Messengercatabolite repressionglycerol dehdrogenaseHfqProQsRNA

Identifiers

PMID35239434
PMCPMC8915982
OpenAlexW4214931110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.