Evidence map›Paper›PMID 35239330›Full record

ArticleACS nano2022

Treatment of Wound Infections in a Mouse Model Using Zn

Huan Peng, Daniele Rossetto, Sheref S Mansy, Maria C Jordan, Kenneth P Roos, Irene A Chen

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 95 citations in OpenAlex.

  1. Review
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  5. Zinc oxide-bacteriophage synergistic combination for dual-mode antibacterial activity against multidrug-resistant Escherichia coli.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
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  14. Article
  15. Real-TimeACS biomaterials science & engineering · 2025
    Article
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  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Huan PengDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, United States.
Daniele RossettoDepartment of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Sheref S MansyDepartment of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.ORCID 0000-0003-2382-198X
Maria C JordanDepartment of Physiology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, United States.
Kenneth P RoosDepartment of Physiology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, United States.
Irene A ChenDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, United States.ORCID 0000-0001-6040-7927
University of California, Los Angeles · USUniversity of Alberta · CA

Funding

Understanding how bacteriophages affect wound ecologies and developing new tools to harness bacteria-phage interactionsDP2GM123457 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI CHEN, IRENE ANN · 2016 to 2016
$2.3M
HIGH-END CRYOEM INSTRUMENT FOR UCLA ELECTRON IMAGING CTR FOR NANOMACHINES: AIDSS10RR023057 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, Z HONG · 2006 to 2006
$1.6M
Multiphoton Microscope for Deep Tissue ImagingS10OD025017 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BENTOLILA, LAURENT A. · 2018 to 2018
$599k
NCRR NIH HHS S10 RR023057NIGMS NIH HHS DP2 GM123457NIH HHS S10 OD025017
6 · The paper itself

Abstract

Infections caused by drug-resistant bacteria, particularly Gram-negative organisms, are increasingly difficult to treat using antibiotics. A potential alternative is "phage therapy", in which phages infect and lyse the bacterial host. However, phage therapy poses serious drawbacks and safety concerns, such as the risk of genetic transduction of antibiotic resistance genes, inconsistent pharmacokinetics, and unknown evolutionary potential. In contrast, metallic nanoparticles possess precise, tunable properties, including efficient conversion of electronic excitation into heat. In this work, we demonstrate that engineered phage-nanomaterial conjugates that target the Gram-negative pathogen

Indexed as

BacteriophagesNanotubesPseudomonas InfectionsWound InfectionAnimalsAnti-Bacterial AgentsDisease Models, AnimalGoldMicePseudomonas aeruginosaZincAnti-Bacterial AgentsGoldZincinfectionphagephage therapyphotothermalPseudomonas aeruginosawound healing

Identifiers

PMID35239330
PMCPMC8981316
OpenAlexW4221052249

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.