Evidence map›Paper›PMID 35239186›Full record

ArticleThe Journal of pathology2022

Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways.

Maria Prendecki, Stephen P McAdoo, Tabitha Turner-Stokes, Ana Garcia-Diaz, Isabel Orriss, Kevin J Woollard, Jacques Behmoaras, H Terence Cook, Robert Unwin, Charles D Pusey and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Animal Models for the Investigation of P2X7 Receptors.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Maria PrendeckiCentre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, Hammersmith Campus, London, UK.ORCID 0000-0001-7048-7457
Stephen P McAdooCentre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, Hammersmith Campus, London, UK.
Tabitha Turner-StokesCentre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, Hammersmith Campus, London, UK.
Ana Garcia-DiazCentre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, Hammersmith Campus, London, UK.
Isabel OrrissDepartment of Comparative Biomedical Sciences, Royal Veterinary College, London, UK.
Kevin J WoollardCentre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, Hammersmith Campus, London, UK.
Jacques BehmoarasCentre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, Hammersmith Campus, London, UK.
H Terence CookCentre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, Hammersmith Campus, London, UK.
Robert UnwinDepartment of Renal Medicine, Division of Medicine, University College London, London, UK.
Charles D PuseyCentre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, Hammersmith Campus, London, UK.
Timothy J AitmanCentre for Genomic & Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Frederick Wk TamCentre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, Hammersmith Campus, London, UK.
Centre for Inflammation Research · GBAstraZeneca (United Kingdom) · GBClinical Trial Investigators · USDuke-NUS Medical School · SGEdinburgh Cancer Research · GBRoyal Veterinary College · GB

Funding

Medical Research Council MC_U120061454Medical Research Council MR/M004716/1Medical Research Council MR/N01121X/1UK MRC MR/M018733/1
6 · The paper itself

Abstract

P2RX7, an ionotropic receptor for extracellular adenosine triphosphate (ATP), is expressed on immune cells, including macrophages, monocytes, and dendritic cells and is upregulated on nonimmune cells following injury. P2RX7 plays a role in many biological processes, including production of proinflammatory cytokines such as interleukin (IL)-1β via the canonical inflammasome pathway. P2RX7 has been shown to be important in inflammation and fibrosis and may also play a role in autoimmunity. We have developed and phenotyped a novel P2RX7 knockout (KO) inbred rat strain and, taking advantage of the human-resembling unique histopathological features of rat models of glomerulonephritis, we induced three models of disease: nephrotoxic nephritis, experimental autoimmune glomerulonephritis, and experimental autoimmune vasculitis. We found that deletion of P2RX7 does not protect rats from models of experimental glomerulonephritis or the development of autoimmunity. Notably, treatment with A-438079, a P2RX7 antagonist, was equally protective in WKY WT and P2RX7 KO rats, revealing its 'off-target' properties. We identified a novel ATP/P2RX7/K

Indexed as

GlomerulonephritisReceptors, Purinergic P2X7VasculitisAdenosine TriphosphateAnimalsCaspase 1CaspasesInflammasomesInflammationInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinRatsRats, Inbred WKYAdenosine TriphosphateCasp4 protein, ratCaspase 1CaspasesInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinP2rx7 protein, ratReceptors, Purinergic P2X7autoimmunitycaspase-1glomerulonephritisIL-1βinflammasomeinflammationNLRP3P2RX7vasculitis

Identifiers

PMID35239186
PMCPMC9322550
OpenAlexW4214835409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.