Evidence map›Paper›PMID 35239017›Full record

ArticleArchives of microbiology2022

Decoding Acinetobacter baumannii biofilm dynamics and associated protein markers: proteomic and bioinformatics approach.

Monika Choudhary, Shubham Kaushik, Arti Kapil, Rahul Shrivastava, Jitendraa Vashistt

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Analysis of variations in cell envelope subproteome and cell length in Acinetobacter baumannii ATCC 19606International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Monika ChoudharyDepartment of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, 173234, Himachal Pradesh, India.ORCID http://orcid.org/0000-0002-6472-525X
Shubham KaushikVProteomics, Valerian Chem Private Limited Green Park Main, New Delhi, 110016, India.ORCID http://orcid.org/0000-0002-9832-7233
Arti KapilDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, 110029, India.
Rahul ShrivastavaDepartment of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, 173234, Himachal Pradesh, India.ORCID http://orcid.org/0000-0003-2031-8369
Jitendraa VashisttDepartment of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, 173234, Himachal Pradesh, India. jvashist@gmail.com.ORCID http://orcid.org/0000-0002-8702-3170
Jaypee University of Information Technology · INAll India Institute of Medical Sciences · IN

Funding

Science and Engineering Research Board YSS/2014/000548
6 · The paper itself

Abstract

Biofilm formation by Acinetobacter baumannii is one of the major cause of its persistence in hospital environment. Biofilm phenotypes are more resistant to physical as well as chemical stresses than their planktonic counterparts. The present study was carried in quest of biofilm-associated protein markers and their association with various biological pathways of A. baumannii. The study was designed with an aim to highlight the crucial common factor present in the majority of the A. baumannii strains irrespective of its resistance nature. A label-free proteome comparison of biofilm and planktonic phenotypes of A. baumannii was done using QExactive tandem mass spectrometry. Our investigation suggests key elevation of adhesion factors, acetate metabolism, nutrient transporters, and secretion system proteins are required for biofilm formation in A. baumannii. Elevation of biofilm-associated proteins revealed that biofilm is the unique phenotype with the potential to form robust matrix-embedded colonies and defeat stress condition. Further, core protein markers of biofilm phenotypes could be used as targets for new clinical interventions to combat biofilm-associated infections.

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsBiofilmsComputational BiologyDrug Resistance, Multiple, BacterialPlanktonProteomicsAnti-Bacterial AgentsAcinetobacter baumanniiAntimicrobial resistanceBiofilmsComparative proteomicsPlanktonic

Identifiers

PMID35239017
OpenAlexW4214825426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.