Evidence map›Paper›PMID 35238706›Full record

ArticleWorld journal for pediatric & congenital heart surgery2022

Biomechanical Analysis of the Ross Procedure in an Ex Vivo Left Heart Simulator.

Amelia Y Bryan, E Brandon Strong, Sumanth Kidambi, Shane Gilligan-Steinberg, Ross Bennett-Kennett, James Y Lee, Annabel Imbrie-Moore, Stephen C Moye, Sebastian Hendrickx-Rodriguez, Hanjay Wang and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal for pediatric & congenital heart surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Amelia Y BryanDepartment of Cardiothoracic Surgery, Stanford University, Palo Alto, CA, USA.
E Brandon StrongDepartment of Cardiothoracic Surgery, Stanford University, Palo Alto, CA, USA.
Sumanth KidambiDepartment of Cardiothoracic Surgery, Stanford University, Palo Alto, CA, USA.
Shane Gilligan-SteinbergDepartment of Cardiothoracic Surgery, Stanford University, Palo Alto, CA, USA.
Ross Bennett-KennettDepartment of Materials Science and Engineering, Stanford University, Palo Alto, CA, USA.
James Y LeeDepartment of Cardiothoracic Surgery, Stanford University, Palo Alto, CA, USA.
Annabel Imbrie-MooreDepartment of Cardiothoracic Surgery, Stanford University, Palo Alto, CA, USA.
Stephen C MoyeDepartment of Cardiothoracic Surgery, Stanford University, Palo Alto, CA, USA.
Sebastian Hendrickx-RodriguezDepartment of Mechanical Engineering, Stanford University, Palo Alto, CA, USA.
Hanjay WangDepartment of Cardiothoracic Surgery, Stanford University, Palo Alto, CA, USA.
Reinhold H DauskardtDepartment of Materials Science and Engineering, Stanford University, Palo Alto, CA, USA.
Y Joseph WooDepartment of Cardiothoracic Surgery, Stanford University, Palo Alto, CA, USA.
Michael R MaDepartment of Cardiothoracic Surgery, Stanford University, Palo Alto, CA, USA.
Stanford University · US

Funding

Institutional Career Development Core (KL2)KL2TR003143 · NCATS · STANFORD UNIVERSITY · PI ASCH, STEVEN M. · 2019 to 2023
$8.7M
ANGIOGENIC TISSUE ENGINEERING TO LIMIT POST-INFARCTION VENTRICULAR REMODELINGR01HL089315 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WOO, Y JOSEPH · 2008 to 2023
$6.4M
NCATS NIH HHS KL2 TR003143NHLBI NIH HHS R01 HL089315
6 · The paper itself

Abstract

backgroundNeo-aortic pulmonary autografts often experience root dilation and valve regurgitation over time. This study seeks to understand the biomechanical differences between aortic and neo-aortic pulmonary roots using a heart simulator.

methodsPorcine aortic, neo-aortic pulmonary, and pulmonary roots (n  =  6) were mounted in a heart simulator (parameters: 100 mm Hg, 37 °C, 70 cycles per minute, 5.0 L/min cardiac output). Echocardiography was used to study root distensibility (percentage change in luminal diameter between systole and diastole) and valve function. Leaflet motion was tracked with high-speed videography. After 30 min in the simulator, leaflet thickness (via cryosectioning), and multiaxial modulus (via lenticular hydrostatic deformation testing) were obtained.

resultsThere were no significant differences between aortic and neo-aortic pulmonary leaflet motion, including mean opening velocity (218 vs 248 mm/s,

conclusionsNeo-aortic pulmonary roots demonstrated equivalence in valve function and distensibility but did experience changes in biomechanical properties and morphology. These changes may contribute to long-term complications associated with the Ross procedure.

Indexed as

Aortic Valve InsufficiencyHeart Valve DiseasesPulmonary ValveAnimalsAortic ValveAutograftsHumansSwineTransplantation, Autologousaortic rootaortic valveautograftpulmonary valvereplacementRoss operation

Identifiers

PMID35238706
PMCPMC11460983
OpenAlexW4214882615

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.