Evidence map›Paper›PMID 35238667›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Molecular mechanism underlying the TLR4 antagonistic and antiseptic activities of papiliocin, an insect innate immune response molecule.

Manigandan Krishnan, Joonhyeok Choi, Ahjin Jang, Sungjae Choi, Jiwon Yeon, Mihee Jang, Yeongjoon Lee, Kkabi Son, Soon Young Shin, Myeong Seon Jeong and 1 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Anti-inflammatory Potential ofCurrent computer-aided drug design · 2025
    Article
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  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Protective Effects of Rhamnetin in Carbapenem-ResistantInternational journal of molecular sciences · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Toll-like Receptor Mediation in SARS-CoV-2: A Therapeutic Approach.International journal of molecular sciences · 2022
    Review
  16. Antimicrobial peptides could antagonize uncontrolled inflammationFrontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Manigandan KrishnanDepartment of Bioscience and Biotechnology, Konkuk University, Seoul 05029, South Korea.ORCID 0000-0002-4998-4405
Joonhyeok ChoiDepartment of Bioscience and Biotechnology, Konkuk University, Seoul 05029, South Korea.ORCID 0000-0003-4286-8281
Ahjin JangDepartment of Bioscience and Biotechnology, Konkuk University, Seoul 05029, South Korea.
Sungjae ChoiDepartment of Bioscience and Biotechnology, Konkuk University, Seoul 05029, South Korea.
Jiwon YeonDepartment of Bioscience and Biotechnology, Konkuk University, Seoul 05029, South Korea.
Mihee JangDepartment of Bioscience and Biotechnology, Konkuk University, Seoul 05029, South Korea.
Yeongjoon LeeDepartment of Bioscience and Biotechnology, Konkuk University, Seoul 05029, South Korea.ORCID 0000-0002-9156-6477
Kkabi SonDepartment of Bioscience and Biotechnology, Konkuk University, Seoul 05029, South Korea.
Soon Young ShinDepartment of Biological Sciences, Konkuk University, Seoul 05029, South Korea.ORCID 0000-0002-1075-0011
Myeong Seon JeongChuncheon Center, Korea Basic Science Institute, Chuncheon 24341, South Korea.
Yangmee KimDepartment of Bioscience and Biotechnology, Konkuk University, Seoul 05029, South Korea.
Konkuk University · KRKorea Basic Science Institute · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SignificanceSimilar to mammalian TLR4/MD-2, the Toll9/MD-2-like protein complex in the silkworm,

Indexed as

AnimalsAnti-Infective Agents, LocalAntimicrobial PeptidesButterfliesEscherichia coli InfectionsFemaleImmunity, InnateInsect ProteinsLipopolysaccharidesMiceMice, Inbred ICRMolecular Docking SimulationProtein BindingProtein ConformationToll-Like Receptor 4Anti-Infective Agents, LocalAntimicrobial PeptidesInsect ProteinsLipopolysaccharidesToll-Like Receptor 4antimicrobial peptideinsect cecropininsect innate immunityLPSToll-like receptor 4

Identifiers

PMID35238667
PMCPMC8915966
OpenAlexW4214858234

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.