Evidence map›Paper›PMID 35238594›Full record

ArticleJournal of psychopathology and clinical science2022

Maternal prenatal infection and anxiety predict neurodevelopmental outcomes in middle childhood.

Thomas G O'Connor, Allison Avrich Ciesla, Ana Vallejo Sefair, Loralei L Thornburg, Alan S Brown, Vivette Glover, Kieran J O'Donnell

Open access · hybridAbstract read
In one paragraph

Article in Journal of psychopathology and clinical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Perceived connectedness during the perinatal period: Implications for parent and child well-being.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2026
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  19. Maternal Immune Activation Hypotheses for Human Neurodevelopment: Some Outstanding Questions.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution.

Thomas G O'ConnorDepartment of Psychiatry.ORCID 0000-0002-8590-5057
Allison Avrich CieslaDepartment of Public Health Sciences.ORCID 0000-0001-8739-1005
Ana Vallejo SefairDepartment of Psychology.ORCID 0000-0003-2900-4120
Loralei L ThornburgDepartment of Obstetrics and Gynecology.
Alan S BrownNew York State Psychiatric Institute.
Vivette GloverInstitute of Reproductive and Developmental Biology.
Kieran J O'DonnellYale Child Study Center.
New York State Psychiatric Institute

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Pre- and Postnatal Exposure Periods for Child Health: Common Risks and Shared MechanismsUH3OD023349 · OD · UNIVERSITY OF ROCHESTER · PI Emily S Barrett, Richard Kermit Miller · 2018 to 2026
$15.9M
Pre- and Postnatal Exposure Periods for Child Health: Common Risks and Shared MechanismsUG3OD023349 · OD · UNIVERSITY OF ROCHESTER · PI BARRETT, EMILY S, MILLER, RICHARD KERMIT · 2016 to 2024
$7.0M
Stress Exposure and Immune Outcomes in ChildrenR01MH097293 · NIMH · UNIVERSITY OF ROCHESTER · PI CASERTA, MARY T, MOYNIHAN, JAN A · 2013 to 2017
$3.6M
Prenatal Anxiety and its Effects on Child DevelopmentR01MH073019 · NIMH · UNIVERSITY OF ROCHESTER · PI O'CONNOR, THOMAS G · 2007 to 2011
$2.8M
Persisting Effects of Prenatal Anxiety on Child OutcomesR01MH073842 · NIMH · UNIVERSITY OF ROCHESTER · PI O'CONNOR, THOMAS G · 2006 to 2010
$2.1M
Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009NCATS NIH HHS UL1 TR001863NIH HHS UG3 OD023349NIH HHS UH3 OD023349NIMH NIH HHS R01 MH073019NIMH NIH HHS R01 MH073842NIMH NIH HHS R01 MH097293
6 · The paper itself

Abstract

Prenatal maternal infection and anxiety have been linked, in separate lines of study, with child neurodevelopment. We extend and integrate these lines of study in a large prospective longitudinal cohort study of child neurodevelopment. Data are based on the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort; prenatal maternal anxiety was assessed from self-report questionnaire; prenatal infection was derived from reports of several conditions in pregnancy (

Indexed as

AnxietyChild Behavior DisordersAnxiety DisordersChildFemaleHumansLongitudinal StudiesPregnancyProspective StudiesVitaminsVitamins

Identifiers

PMID35238594
PMCPMC9069845
OpenAlexW4221121940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.