Evidence map›Paper›PMID 35238582›Full record

ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2022

Prospective self- and informant-personality associations with inflammation, health behaviors, and health indicators.

Amanda J Wright, Sara J Weston, Sara Norton, Michaela Voss, Ryan Bogdan, Thomas F Oltmanns, Joshua J Jackson

Abstract read
In one paragraph

Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Socioemotional Engagement With Grandchildren: Associations With Loneliness and Quality of Life.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025
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  8. Article
  9. Personality and falls: evidence from three samples.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Personality and Cognition: The Mediating Role of Inflammatory Markers.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024
    Article
  14. Article
  15. Personality and aging-related immune phenotype.Psychoneuroendocrinology · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. The Role of Personality in the Mental and Physical Health of World Trade Center Responders: Self- versus Informant-Reports.Clinical psychological science : a journal of the Association for Psychological Science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amanda J WrightDepartment of Psychological and Brain Sciences, Washington University in St. Louis.ORCID 0000-0001-8873-9405
Sara J WestonDepartment of Psychology, University of Oregon.ORCID 0000-0001-7782-6239
Sara NortonDepartment of Psychological and Brain Sciences, Washington University in St. Louis.
Michaela VossDepartment of Psychological and Brain Sciences, Washington University in St. Louis.
Ryan BogdanDepartment of Psychological and Brain Sciences, Washington University in St. Louis.ORCID 0000-0002-1430-1045
Thomas F OltmannsDepartment of Psychological and Brain Sciences, Washington University in St. Louis.
Joshua J JacksonDepartment of Psychological and Brain Sciences, Washington University in St. Louis.ORCID 0000-0002-9490-8890

Funding

Intergenerational Transmission of Stress: Psychosocial and Biological MechanismsR01AG061162 · NIA · WASHINGTON UNIVERSITY · PI BOGDAN, RYAN H · 2019 to 2023
$3.1M
Personality and Health in Later Life: Psychosocial and Biological MechanismsR01AG045231 · NIA · WASHINGTON UNIVERSITY · PI OLTMANNS, THOMAS · 2014 to 2018
$2.9M
NIA NIH HHS R01 AG045231NIA NIH HHS R01 AG061162
6 · The paper itself

Abstract

objectivePersonality influences many aspects of the health process. It is unclear to what extent self- and informant-reports of the Big Five offer incremental validity for the prediction of inflammatory biomarkers and whether inflammation provides a unique pathway between personality and indicators of physical health, independent of health behaviors.

methodUsing data from older adults (N = 1,630) enrolled in the St. Louis Personality and Aging Network study, we tested whether self- and informant-reported Big Five traits show unique associations with inflammation (IL-6, CRP, TNF-α). Further, we tested whether inflammation and health behaviors indirectly link personality to health-related quality of life, body mass index, and chronic disease burden using longitudinal mediation in a structural equation modeling framework.

resultsSelf-reports, informant-reports, and general trait factors of personality predicted future inflammatory biomarker levels (unstandardized regression coefficients ranged -.08 to .07 for self, -.13 to -.10 for informants, and -.16 to -.11 for general). Additionally, all assessment methods of personality were associated with the indicators of physical health through biomarker and health behavior pathways. Effects were primarily found for conscientiousness and neuroticism; IL-6 and CRP were the biomarkers with the most indirect effects; and indirect paths overall emerged more frequently through health behaviors, but this varied by outcome.

conclusionsSelf- and informant-reports provided unique predictive validity of inflammatory biomarkers. Findings highlight the benefits of using of multiple assessments of personality and the importance of examining multiple, distinct pathways by which personality might influence health to understand the mechanisms underlying this relationship more fully. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Indexed as

PersonalityQuality of LifeAgedHealth BehaviorHumansInflammationProspective Studies

Identifiers

PMID35238582
PMCPMC9775638

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.