ArticleThe Journal of infectious diseases2021
Salmonella Typhi Shedding and Household Transmission by Children With Blood Culture-Confirmed Typhoid Fever in Vellore, South India.
Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Review
- Asymptomatic Carriage and Antimicrobial Resistance ofMicroorganisms · 2026Article
- Gastrointestinal Panel Performance for the Diagnosis of Acute Gastroenteritis in Pediatric Patients.Cureus · 2024Article
- Vibrio cholerae and Salmonella Typhi culture-based wastewater or non-sewered sanitation surveillance in a resource-limited region.Journal of exposure science & environmental epidemiology · 2024Article
- Environmental Surveillance for Salmonella Typhi and its Association With Typhoid Fever Incidence in India and Malawi.The Journal of infectious diseases · 2024Article
- Fecal Shedding, Antimicrobial Resistance andInternational journal of clinical microbiology · 2024Article
- What is the functional reach of wastewater surveillance for respiratory viruses, pathogenic viruses of concern, and bacterial antibiotic resistance genes of interest?Human genomics · 2023Review
- Zingerone inhibits biofilm formation and enhances antibiotic efficacy against Salmonella biofilm.World journal of microbiology & biotechnology · 2023Article
- One species, different diseases: the unique molecular mechanisms that underlie the pathogenesis of typhoidal Salmonella infections.Current opinion in microbiology · 2023Review
- Spatial-temporal and phylogenetic analyses of epidemiologic data to help understand the modes of transmission of endemic typhoid fever in Samoa.PLoS neglected tropical diseases · 2022Article
- Detection of Salmonella Typhi in Bile by Quantitative Real-Time PCR.Microbiology spectrum · 2022Article
- Typhoid in India: An Age-old Problem With an Existing Solution.The Journal of infectious diseases · 2021Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundChildren suffer the highest burden of the typhoid fever, with a considerable proportion shedding Salmonella Typhi in stool, potentially resulting in transmission of S Typhi.
methodsWe enrolled 70 children with blood culture-confirmed typhoid fever (index cases), from 63 households, during community-based fever surveillance in India. The index cases and their household contacts were followed up with stool samples at multiple time points over 3 weeks and 1 week, respectively. S Typhi was detected using quantitative real-time polymerase chain reaction.
resultsFifteen of 70 (21.4%) children with culture-confirmed typhoid fever shed S Typhi in stool after onset of fever. Ten of 15 children shed S Typhi for a median of 11.5 (range, 3-61) days from the day of completion of antibiotics. Of 172 household contacts from 56 of the 63 index case households, 12 (7%) contacts in 11 (19.6%) households had S Typhi in stool. Five of the 12 contacts who were shedding S Typhi were asymptomatic, whereas 7 reported recent fever.
conclusionsOne in 5 children with typhoid fever shed S Typhi, with shedding persisting even after antibiotics. One in 5 households had at least 1 contact of the child shedding S Typhi, highlighting potential concurrent typhoid infections in households in settings with poor water and sanitation.
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