ArticleAmerican journal of epidemiology2022
The Associations of Dietary Copper With Cognitive Outcomes.
Article in American journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Dietary Copper Intake and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies.Calcified tissue international · 2025Pooled it
- Mechanisms and Pathogenesis of Diabetic Cognitive Impairment: A Comprehensive Review.Aging and disease · 2025Pooled it
- Association of dietary copper intake with Alzheimer's disease, brain structure and cognitive function.The journal of nutrition, health & aging · 2026Article
- Chicken Liver from Broilers Fed Wheat Germ Expeller: A Source of Minerals and Energy in the Human Diet.Foods (Basel, Switzerland) · 2025Article
- Survey of practices of handling exposure measurement errors in modern epidemiology: are the best practices in statistics being adopted by epidemiologists?BMC medical research methodology · 2025Article
- Association between Copper Exposure and Cognitive Function: A Cross-Sectional Study in a County, Guangxi, China.Biological trace element research · 2025Article
- The Role of Copper Intake in Bone Health: A Quantitative Analysis in Postmenopausal Spanish Women.European journal of investigation in health, psychology and education · 2025Article
- U-shaped nonlinear relationship between dietary copper intake and peripheral neuropathy.Scientific reports · 2024Article
- Associations of the Mediterranean-DASH Intervention for Neurodegenerative Delay diet with brain structural markers and their changes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The associations of dietary manganese, iron, copper, zinc, selenium and magnesium with cognitive outcomes in Chinese adults: a cross sectional study in Shanghai.Frontiers in nutrition · 2024Article
- Co-Administration of Roxadustat and Zinc Stabilizes Both Serum Copper and Zinc Concentrations in Patients Undergoing Hemodialysis.Nutrients · 2023Article
- Association between Mineral Intake and Cognition Evaluated by Montreal Cognitive Assessment (MoCA): A Cross-Sectional Study.Nutrients · 2023Article
- Dietary Intake Levels of Iron, Copper, Zinc, and Manganese in Relation to Cognitive Function: A Cross-Sectional Study.Nutrients · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Dietary copper intake may be associated with cognitive decline and dementia. We used data from 10,269 participants of the Atherosclerosis Risks in Communities Study to study the associations of dietary copper intake with 20-year cognitive decline and incident dementia. Dietary copper intake from food and supplements was quantified using food frequency questionnaires. Cognition was assessed using 3 cognitive tests at study visits; dementia was ascertained at study visits and via surveillance. Multiple imputation by chained equations was applied to account for the missing information of cognitive function during follow-up. Survival analysis with parametric models and mixed-effect models were used to estimate the associations for incident dementia and cognitive decline, respectively. During 20 years of follow-up (1996-1998 to 2016-2017), 1,862 incident cases of dementia occurred. Higher intake of dietary copper from food was associated with higher risk of incident dementia among those with high intake of saturated fat (hazard ratio = 1.49, 95% confidence interval: 1.04, 1.95). Higher intake of dietary copper from food was associated with greater decline in language overall (beta = -0.12, 95% confidence interval: -0.23, -0.02). Therefore, a diet high in copper, particularly when combined with a diet high in saturated fat, may increase the risk of cognitive impairment.
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Registered trials
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