Evidence map›Paper›PMID 35238181›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology2022

Clinical magnetic hyperthermia requires integrated magnetic particle imaging.

Sean Healy, Andris F Bakuzis, Patrick W Goodwill, Anilchandra Attaluri, Jeff W M Bulte, Robert Ivkov

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Verification and validation in canine cadaver of an MPI-integrable RF head coil for magnetic particle hyperthermia.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026
    Article
  2. Review
  3. Spatiotemporal cancer controlNanomedicine (London, England) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sean HealyDepartment of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Andris F BakuzisInstituto de Física and CNanoMed, Universidade Federal de Goiás, Goiânia, GO, Brazil.
Patrick W GoodwillMagnetic Insight, Inc., Alameda, California, USA.
Anilchandra AttaluriDepartment of Mechanical Engineering, Pennsylvania State University, Harrisburg, Harrisburg, Pennsylvania, USA.
Jeff W M BulteDepartment of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Robert IvkovDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-2930-5276

Funding

Translational Application of Magnetic Hyperthermia Therapy with Adjuvant Therapies for GlioblastomaR01CA247290 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HADJIPANAYIS, CONSTANTINOS GEORGE, IVKOV, ROBERT · 2020 to 2024
$3.5M
Enhancing Liver Cancer Treatment With Image-Guided Magnetic HyperthermiaR01CA194574 · NCI · JOHNS HOPKINS UNIVERSITY · PI IVKOV, ROBERT · 2015 to 2019
$3.2M
Precision magnetic hyperthermia by integrating magnetic particle imagingR01CA257557 · NCI · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W., IVKOV, ROBERT · 2021 to 2025
$3.2M
Color MPI as a novel method for in vivo assessment of magnetic nanoparticle dynamics and bindingR44EB029877 · NIBIB · MAGNETIC INSIGHT, INC. · PI GOODWILL, PATRICK · 2020 to 2021
$1.6M
Non-Invasive Tracking of Genome-Corrected iPS cells in ALSUH3EB028904 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2021 to 2022
$950k
Magnetic Particle Imaging ScannerS10OD026740 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI BULTE, JEFF W. · 2019 to 2019
$600k
NCI NIH HHS R01 CA194574NCI NIH HHS R01 CA247290NCI NIH HHS R01 CA257557NIBIB NIH HHS R44 EB029877NIH HHS 1R01 CA257557NIH HHS 5R01 CA194574-02NIH HHS 5R01 CA247290NIH HHS R44 EB029877NIH HHS S10 OD026740NIH HHS UH 3EB028904
6 · The paper itself

Abstract

Magnetic nanomaterials that respond to clinical magnetic devices have significant potential as cancer nanotheranostics. The complexities of their physics, however, introduce challenges for these applications. Hyperthermia is a heat-based cancer therapy that improves treatment outcomes and patient survival when controlled energy delivery is combined with accurate thermometry. To date, few technologies have achieved the needed evolution for the demands of the clinic. Magnetic fluid hyperthermia (MFH) offers this potential, but to be successful it requires particle-imaging technology that provides real-time thermometry. Presently, the only technology having the potential to meet these requirements is magnetic particle imaging (MPI), for which a proof-of-principle demonstration with MFH has been achieved. Successful clinical translation and adoption of integrated MPI/MFH technology will depend on successful resolution of the technological challenges discussed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > In Vivo Nanodiagnostics and Imaging.

Indexed as

Hyperthermia, InducedMagnetite NanoparticlesNeoplasmsDiagnostic ImagingHumansMagnetic PhenomenaMagnetite NanoparticlesCancermagnetic fluid hyperthermiamagnetic nanoparticlesmagnetic particle imagingtheranostics

Identifiers

PMID35238181
PMCPMC9107505

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.