Trial reportClinical oral implants research2022
Non-surgical peri-implantitis treatment with or without systemic antibiotics: a randomized controlled clinical trial.
Trial report in Clinical oral implants research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Impact and efficacy of systemic antibiotics for peri-implant diseases treatment: A systematic review and meta-analysis on clinical and microbiological outcomes.Periodontology 2000 · 2025Pooled it
- Efficacy of adjunctive systemic or local antibiotic therapy in peri-implantitis: a systematic review and meta-analysis of randomized controlled clinical trials.Journal of Zhejiang University. Science. B · 2024Pooled it
- Clinical efficacy of adjunctive methods for the non-surgical treatment of peri-implantitis: a systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Efficacy of adjuvant metronidazole therapy on peri-implantitis: a systematic review and meta-analysis of randomized clinical studies.Frontiers in cellular and infection microbiology · 2023Pooled it
- Peri-implantitis reconstructive treatment implementing a titanium brush: 5-year extension results from a randomized clinical trial.Journal of periodontology · 2025Trial
- Bone Substitute Material in the Surgical Therapy of Peri-Implantitis-3-Year Outcomes of a Randomized Controlled Trial.Clinical oral implants research · 2025Trial
- Non-surgical peri-implantitis treatment with or without systemic antibiotics: a randomized controlled clinical trial.Clinical oral implants research · 2022Trial
- Surgical Therapy for Peri-Implantitis Using Deproteinised Bovine Bone Mineral With 10% Collagen, Enamel Matrix Derivative and Doxycycline: A Prospective Cohort 10-Year Implant Study.Journal of clinical periodontology · 2026Article
- Antibacterial silver ion-coated dental implants suppress peri-implantitis in a murine model.Scientific reports · 2026Article
- Risk-based efficacy of systemic and local antibiotics in nonsurgical treatment of peri-implantitis: A systematic review and meta-analysis.Journal of advanced periodontology & implant dentistry · 2026Article
- Adjunctive effect of soft tissue grafting in the surgical treatment of peri-implantitis: clinical and radiographic outcomes from a preclinical canine experiment.Journal of periodontal & implant science · 2026Article
- Clinical efficacy of hyaluronic acid in peri-implantitis treatment: a systematic review of clinical, radiographic, and biological outcomes.Biomaterial investigations in dentistry · 2026Review
- Evaluation of a Gel Loaded With M101 on Bone and Peri-Implantitis Healing: An Experimental In Vivo Study.Clinical oral implants research · 2025Article
- The systemic impact of non-surgical treatment of peri-implantitis with or without adjunctive systemic metronidazole: Secondary analysis of a randomized clinical trial.Clinical oral implants research · 2024Article
- Assessing peri-implant bacterial community structure: the effect of microbiome sample collection method.BMC oral health · 2024Article
- Novel Flowchart Guiding the Non-Surgical and Surgical Management of Peri-Implant Complications: A Narrative Review.Bioengineering (Basel, Switzerland) · 2024Review
- Article
- Outcome indicators of non-surgical therapy of peri-implantitis: a prospective case series analysis.Clinical oral investigations · 2023Article
- Non-Surgical Therapy and Oral Microbiota Features in Peri-Implant Complications: A Brief Narrative Review.Healthcare (Basel, Switzerland) · 2023Review
- Metabolic Conditions and Peri-Implantitis.Antibiotics (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
objectivesTo assess the adjunctive effect of systemic amoxicillin (AMX) and metronidazole (MTZ) in patients receiving non-surgical treatment (NST) for peri-implantitis (PI). MATERIALS AND
methodsThirty-seven patients were randomized into an experimental group treated with NST plus AMX + MTZ (N = 18) and a control group treated with NST alone (N = 19). Clinical parameters were evaluated at 12 weeks post-treatment. The primary outcome was the change in peri-implant pocket depth (PIPD) from baseline to 12 weeks, while secondary outcomes included bleeding on probing (BoP), suppuration on probing (SoP), and plaque. Data analysis was performed at patient level (one target site per patient).
resultsAll 37 patients completed the study. Both groups showed a significant PIPD reduction after NST. The antibiotics group showed a higher mean reduction in PIPD at 12 weeks, compared with the control group (2.28 ± 1.49 mm vs. 1.47 ± 1.95 mm), however, this difference did not reach statistical significance. There was no significant effect of various potential confounders on PIPD reduction. Neither treatment resulted in significant improvements in BoP at follow-up; 30 of 37 (81%) target sites still had BoP after treatment. Only two implants, one in each group, exhibited a successful outcome defined as PIPD < 5 mm, and absence of BoP and SoP.
conclusionsNon-surgical treatment was able to reduce PIPD at implants with PI. The adjunctive use of systemic AMX and MTZ did not show statistically significant better results compared to NST alone. NST with or without antibiotics was ineffective to completely resolve inflammation around dental implants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.