Evidence map›Paper›PMID 35237994›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Intravital Microscopy in Atherosclerosis Research.

Georg Wissmeyer, Mohamad B Kassab, Yoichiro Kawamura, Aaron D Aguirre, Farouc A Jaffer

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Georg WissmeyerCardiovascular Research Center, Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mohamad B KassabCardiovascular Research Center, Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yoichiro KawamuraCardiovascular Research Center, Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Aaron D AguirreWellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.
Farouc A JafferCardiovascular Research Center, Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. fjaffer@mgh.harvard.edu.
Harvard University · USMassachusetts General Hospital · US

Funding

Novel PET/CT and Treatment Strategies to reduce PTS following DVTR01HL137913 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JAFFER, FAROUC AMIN, TAWAKOL, AHMED A · 2017 to 2020
$3.3M
Intravascular NIRF-IVUS imaging of inflammation-guided arterial therapyR01HL150538 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JAFFER, FAROUC AMIN · 2020 to 2023
$2.2M
Dynamic Single Cell Imaging of Coronary Microvascular Dysfunction in the Failing HeartR01HL144515 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI AGUIRRE, AARON D · 2019 to 2023
$2.1M
NHLBI NIH HHS R01 HL137913NHLBI NIH HHS R01 HL144515NHLBI NIH HHS R01 HL150538
6 · The paper itself

Abstract

Atherosclerosis is a lipid-driven inflammatory disorder that narrows the arterial lumen and can induce life-threatening complications from coronary artery disease, cerebrovascular disease, and peripheral artery disease. On a mechanistic level, the development of novel cellular-resolution intravital microscopy imaging approaches has recently enabled in vivo studies of underlying biological processes governing disease onset and progress. In particular, multiphoton microscopy has emerged as a promising intravital imaging tool utilizing two-photon-excited fluorescence and second-harmonic generation that provides subcellular resolution and increased imaging depths beyond confocal and epifluorescence microscopy. In this chapter, we describe the state-of-the-art multiphoton microscopy applied to the study of murine atherosclerosis.

Indexed as

AtherosclerosisMicroscopy, Fluorescence, MultiphotonAnimalsIntravital MicroscopyMicePhotonsAtherosclerosisGated microscopyInflammationIntravital imagingIntravital microscopyMolecular imagingMultiphoton microscopy

Identifiers

PMID35237994
PMCPMC9052099
OpenAlexW4214912729

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.