Evidence map›Paper›PMID 35237754›Full record

ArticleClinical pathology (Thousand Oaks, Ventura County, Calif.)

Disseminated Cryptococcal Infection in HIV-Infected Patients: A Retrospective Clinicopathological Review of 4 Autopsy Cases.

Moshawa Calvin Khaba, Mamokoma Becky Kgole, Lesedi Makgwethele Nevondo, Willem Johannes Van Aswegen, Tshegofatso Mabelane, Ndivhuho Agnes Makhado

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical pathology (Thousand Oaks, Ventura County, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Moshawa Calvin KhabaDepartment of Anatomical Pathology, Dr George Mukhari Academic Laboratory, National Health Laboratory Service, Sefako Makgatho Health Sciences University, Ga-Rankuwa, South Africa.ORCID https://orcid.org/0000-0001-6999-6836
Mamokoma Becky KgoleDepartment of Internal Medicine, Dr George Mukhari Academic Hospital, Sefako Makgatho Health Sciences University, Ga-Rankuwa, South Africa.
Lesedi Makgwethele NevondoDepartment of Anatomical Pathology, Dr George Mukhari Academic Laboratory, National Health Laboratory Service, Sefako Makgatho Health Sciences University, Ga-Rankuwa, South Africa.
Willem Johannes Van AswegenDepartment of Internal Medicine, Dr George Mukhari Academic Hospital, Sefako Makgatho Health Sciences University, Ga-Rankuwa, South Africa.
Tshegofatso MabelaneDepartment of Family Medicine, Job Shimankana Tabane Hospital, Sefako Makgatho Health Sciences University, Ga-Rankuwa, South Africa.
Ndivhuho Agnes MakhadoDepartment of Medical Microbiology, Dr George Mukhari Academic Laboratory, National Health Laboratory Services, Sefako Makgatho Health Sciences University, Ga-Rankuwa, South Africa.
National Health Laboratory Service · ZASefako Makgatho Health Sciences University · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cryptococcosis is an opportunistic infection with high mortality if not diagnosed and treated in time. The objective of this study was to review the clinicopathological information of decendents with final autopsy diagnosis of disseminated cryptococcal infection. This study collected data from 4 decendents who presented to an academic hospital/laboratory between 1 January 2015 to 31 December 2018. Their clinical, radiological and pathological findings including treatment were reviewed. Two decendents presented with respiratory symptoms whilst the other 2 presented with meningeal symptoms. Three were confirmed HIV positive. One decendent was on ART, one had defaulted treatment and one was ART naïve. Two decendents were diagnosed with cryptococcal meningitis, one with bacterial pneumonia and one with pulmonary tuberculosis. Three decendents died in emergency unit and one in the ward whilst on antifungal therapy. The autopsy findings confirmed disseminated cryptococcal infection in all cases. A high index of suspicion should be maintained in the right clinical context. Multi-organ involvement should be suspected in all patients and be actively sought out.

Indexed as

acquired immunodeficiency syndromeautopsyCryptococcosisdisseminatedhuman immunodeficiency virus

Identifiers

PMID35237754
PMCPMC8883375
OpenAlexW4213428711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.