Evidence map›Paper›PMID 35237685›Full record

ArticleERJ open research2022

Does DNA methylation mediate the association of age at puberty with forced vital capacity or forced expiratory volume in 1 s?

Liang Li, Hongmei Zhang, John W Holloway, Susan Ewart, Caroline L Relton, S Hasan Arshad, Wilfried Karmaus

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Liang LiDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
Hongmei ZhangDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.ORCID https://orcid.org/0000-0003-3557-0364
John W HollowayHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0001-9998-0464
Susan EwartCollege of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
Caroline L ReltonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
S Hasan ArshadClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Wilfried KarmausDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.ORCID https://orcid.org/0000-0003-2684-1492
University of Memphis · USMichigan State University · USSt Mary's Hospital · GBUniversity of Bristol · GBUniversity of Southampton · GB

Funding

Does epigenetic methylation explain the gender-switch in adolescent asthma?R01AI121226 · NIAID · UNIVERSITY OF MEMPHIS · PI HOLLOWAY, JOHN W, ZHANG, HONGMEI · 2016 to 2020
$3.2M
Transgenerational epigenetic inheritance of allergy in a multigenerational cohortR01AI091905 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KARMAUS, WILFRIED JJ · 2011 to 2015
$2.7M
Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescenceR01HL082925 · NHLBI · ST. MARY'S HOSPITAL NEWPORT · PI ARSHAD, SYED HASAN · 2007 to 2010
$1.7M
Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/5NHLBI NIH HHS R01 HL082925NIAID NIH HHS R01 AI091905NIAID NIH HHS R01 AI121226Wellcome Trust
6 · The paper itself

Abstract

backgroundAge of pubertal onset is associated with lung function in adulthood. However, the underlying role of epigenetics as a mediator of this association remains unknown.

methodsDNA methylation (DNAm) in peripheral blood was measured at age 18 years in the Isle of Wight birth cohort (IOWBC) along with data on age of pubertal events, forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV

resultsIn the IOWBC, for females, 21 cytosine-phosphate-guanine sites (CpGs) were shown to mediate the association of age at puberty with FVC or FEV

conclusionsOur findings suggest that post-adolescence DNAm in peripheral blood is likely not to mediate the association of age at pubertal onset with young adulthood FVC or FEV

Identifiers

PMID35237685
PMCPMC8883177
OpenAlexW4210303454

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.