Evidence map›Paper›PMID 35237664›Full record

ArticleFrontiers in molecular biosciences2022

Influence of the Dynamically Disordered N-Terminal Tail Domain on the Amyloid Core Structure of Human Y145Stop Prion Protein Fibrils.

Zhe Qi, Krystyna Surewicz, Witold K Surewicz, Christopher P Jaroniec

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Structural Insights into Seeding Mechanisms of hIAPP Fibril Formation.Journal of the American Chemical Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zhe QiDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, United States.
Krystyna SurewiczDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States.
Witold K SurewiczDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States.
Christopher P JaroniecDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, United States.
Case Western Reserve University · USThe Ohio State University · US

Funding

Molecular Mechanisms of Prion and Amyloid PropagationR01GM094357 · NIGMS · OHIO STATE UNIVERSITY · PI JARONIEC, CHRISTOPHER P · 2011 to 2022
$3.2M
800 MHz Solid-State NMR Spectrometer for Biomacromolecular Structure and DynamicsS10OD012303 · OD · OHIO STATE UNIVERSITY · PI JARONIEC, CHRISTOPHER P · 2012 to 2012
$2.0M
NIGMS NIH HHS R01 GM094357NIH HHS S10 OD012303
6 · The paper itself

Abstract

The Y145Stop mutant of human prion protein (huPrP23-144) is associated with a familial prionopathy and provides a convenient

Indexed as

amyloidintrinsically disordered region/proteinmagic angle spinning (MAS) solid-state NMRoctarepeatprion

Identifiers

PMID35237664
PMCPMC8883029
OpenAlexW4212910174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.