Evidence map›Paper›PMID 35237272›Full record

ArticleFrontiers in immunology2022

Antigen-Specific CD4

Kai M T Sauerwein, Christoph B Geier, Roman F Stemberger, Hüseyin Akyaman, Peter Illes, Michael B Fischer, Martha M Eibl, Jolan E Walter, Hermann M Wolf

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  8. Review
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  10. Review
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  12. Immunizing the imperfect immune system: Coronavirus disease 2019 vaccination in patients with inborn errors of immunity.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Review
  13. COVID-19 and Inborn Errors of Immunity.Physiology (Bethesda, Md.) · 2022
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Kai M T SauerweinImmunology Outpatient Clinic, Vienna, Austria.
Christoph B GeierImmunology Outpatient Clinic, Vienna, Austria.
Roman F StembergerImmunology Outpatient Clinic, Vienna, Austria.
Hüseyin AkyamanImmunology Outpatient Clinic, Vienna, Austria.
Peter IllesUSF Health Department of Pediatrics, Division of Allergy/Immunology, Children´s Research Institute, St. Petersburg, FL, United States.
Michael B FischerDepartment for Biomedical Research, Center of Experimental Medicine, Danube University Krems, Krems an der Donau, Austria.
Martha M EiblImmunology Outpatient Clinic, Vienna, Austria.
Jolan E WalterDivision of Allergy and Immunology, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Hermann M WolfImmunology Outpatient Clinic, Vienna, Austria.
Bio Forschung Austria · ATMedical University of Vienna · ATSigmund Freud University Vienna · ATUniversität für Weiterbildung Krems · ATUniversity of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies on immune responses following COVID-19 vaccination in patients with common variable immunodeficiency (CVID) were inconclusive with respect to the ability of the patients to produce vaccine-specific IgG antibodies, while patients with milder forms of primary antibody deficiency such as immunoglobulin isotype deficiency or selective antibody deficiency have not been studied at all. In this study we examined antigen-specific activation of CXCR5-positive and CXCR5-negative CD4

Indexed as

AdultAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineCD4-Positive T-LymphocytesCommon Variable ImmunodeficiencyCOVID-19EnterotoxinsFemaleHumansImmunoglobulin GLymphocyte ActivationMaleMemory T CellsMiddle AgedPrimary Immunodeficiency DiseasesAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineCXCR5 protein, humanenterotoxin B, staphylococcalEnterotoxinsImmunoglobulin GReceptors, Antigen, T-CellReceptors, CXCR5activation induced marker assaycirculating follicular T helper cellscommon variable immunodeficiencyCXCR5-negative CD4+ memory T cellsprimary immunoglobulin isotype deficiencysurrogate virus neutralization assay

Identifiers

PMID35237272
PMCPMC8882590
OpenAlexW4212833105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.