Evidence map›Paper›PMID 35237155›Full record

ReviewFrontiers in pharmacology2022

Recent Progress of Novel Nanotechnology Challenging the Multidrug Resistance of Cancer.

Chengyuan Zhang, Xuemei Zhou, Hanyi Zhang, Xuanliang Han, Baijun Li, Ran Yang, Xing Zhou

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chengyuan ZhangSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
Xuemei ZhouSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
Hanyi ZhangSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
Xuanliang HanSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
Baijun LiSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
Ran YangSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
Xing ZhouSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug resistance (MDR) of tumors is one of the clinical direct reasons for chemotherapy failure. MDR directly leads to tumor recurrence and metastasis, with extremely grievous mortality. Engineering a novel nano-delivery system for the treatment of MDR tumors has become an important part of nanotechnology. Herein, this review will take those different mechanisms of MDR as the classification standards and systematically summarize the advances in nanotechnology targeting different mechanisms of MDR in recent years. However, it still needs to be seriously considered that there are still some thorny problems in the application of the nano-delivery system against MDR tumors, including the excessive utilization of carrier materials, low drug-loading capacity, relatively narrow targeting mechanism, and so on. It is hoped that through the continuous development of nanotechnology, nano-delivery systems with more universal uses and a simpler preparation process can be obtained, for achieving the goal of defeating cancer MDR and accelerating clinical transformation.

Indexed as

cancermechanismmultidrug resistancenanotechnologyreview

Identifiers

PMID35237155
PMCPMC8883114

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.