ReviewNeuropsychiatric disease and treatment2022
Depression in Osteoarthritis: Current Understanding.
Review in Neuropsychiatric disease and treatment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Psychological Interventions Added to Standard Care Improve Pain and Function Outcomes in Knee Osteoarthritis: A Systematic Review and Meta-Analysis.Musculoskeletal care · 2025Pooled it
- Effects of mind-body exercise on knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2024Pooled it
- Effects of TENS with home exercise improve pain and muscle strength in older adults with pre-radiographic to mild knee osteoarthritis.Scientific reports · 2025Trial
- The role of adipose-derived stem cells in knee osteoarthritis treatment: insights from a triple-blind clinical study.Stem cell research & therapy · 2025Trial
- Body composition is associated with changes in health-related quality of life in patients with knee and/or hip osteoarthritis.RMD open · 2025Trial
- Exploring the impact of integrated polyvagal exercises and knee reinforcement in females with grade II knee osteoarthritis: a randomized controlled trial.Scientific reports · 2023Trial
- Re-examining the pain-depression vicious cycle in knee osteoarthritis: a random-intercept cross-lagged panel analysis.BMC musculoskeletal disorders · 2026Article
- Multi-Trajectories of Sleep Disturbance and Depressive Symptoms and Incident Osteoarthritis: Evidence From the English Longitudinal Study of Ageing.Brain and behavior · 2026Article
- Arthritis/Rheumatism and Depressive Symptoms in Middle-Aged and Older Chinese Adults: Regression and Symptom Network Evidence from CHARLS 2018.Healthcare (Basel, Switzerland) · 2026Article
- Psychological distress and functional disability in knee osteoarthritis: a cross-sectional analytical study.BMC musculoskeletal disorders · 2026Article
- Clinical care patterns in the 10-years prior to primary total hip replacement: a matched population-based case-control analysis in England.BMC medicine · 2026Article
- Osteoarthritis pain inversely correlates with histidine and glutamine following CSF and serum profiling.Arthritis research & therapy · 2026Article
- Article
- Considering mental function for successful total knee arthroplasty in older people.World journal of methodology · 2026Article
- Clinical Associations and Possible Risk Factors for Affective Neuropsychiatric Symptoms in Older Adults With and Without Cognitive Impairment.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Plasma fatty acids reflect pain, disability, and psychological well-being in knee osteoarthritis in a longitudinal study with joint replacement surgery.Scientific reports · 2026Article
- The Link Between Depression, Analgesia Usage and Function in Osteoarthritis: A Propensity Score-Matched Analysis from the Osteoarthritis Initiative Cohort.Bioengineering (Basel, Switzerland) · 2026Article
- Brain-bone axis dysregulation: Biological code underlying the bidirectional association between depression and musculoskeletal disorders.Journal of orthopaedic translation · 2026Review
- High prevalence of depression in symptomatic knee osteoarthritis: a cross-sectional study on risk factors and therapeutic implications.BMC musculoskeletal disorders · 2025Observational
- The impact of osteoarthritis and geriatric depression scale on mini-mental state examination trajectories over seven years.European journal of ageing · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression, one of the most common comorbidities with osteoarthritis (OA), affects patient prognosis and quality of life. It also increases the overall burden of disease. This subgroup of patients has not been effectively managed in clinical settings. The study aimed to direct physicians' attention to the co-occurrence of depression and OA. Therefore, this review summarizes the relevant literature published over the past 10 years. The focus is on the prevalence of and risk factors for depression in OA, the effects of depression on OA development and treatment response, comorbidity mechanisms, screening, and non-pharmacological treatment. The research on the etiology of depression has been driven largely by epidemiological studies. Recent studies have shown that high levels of pain, poor levels of function, high numbers of OA sites, and slow gait might be associated with depression. However, the pathophysiology of OA and depression comorbidities remains unclear. In addition to immune inflammation and structural changes in the brain, which have been documented in brain imaging studies, psychosocial factors may also play a role. The evidence indicates that depression can be treated with early intervention; however, adjustments may need to be made for individuals with comorbid depression in OA. It is recommended that health care providers pay more attention to depressive symptoms in patients with OA. Clinicians should develop and implement an individualized and comprehensive treatment plan for patients based on a mental health assessment and in teams with other professionals to optimize treatment outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.