ArticleNature2022
Molecular hallmarks of heterochronic parabiosis at single-cell resolution.
Open access · goldAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
33.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 139 citations in OpenAlex.
- Human microphysiological systems of aging recreate the in vivo process expediting evaluation of anti-geronic strategies.Nature biomedical engineering · 2026Article
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- The Hallmarks of Aging: From Molecular Mechanisms to Clinical Translation.International journal of molecular sciences · 2026Review
- TNFR1 signaling connects inflammation to impaired fatty acid oxidation to drive intestinal stem cell aging.Nature aging · 2026Article
- Biological aging clocks in health and disease.Nature medicine · 2026Review
- Blood serum from individuals with Alzheimer's disease alters microglial phagocytosis in vitro.Neural regeneration research · 2026Article
- Nuclear-Mitochondria Crosstalk in Senescent Adipose-Derived Stem Cells.Smart medicine · 2026Review
- From whole-body to organ-specific biological age clocks.Nature aging · 2026Review
- Expression of progerin enhances disease-related endpoints in a tau seeding reporter cell system.GeroScience · 2026Article
- Blood as the mirror and modulator of aging: mechanistic insights and rejuvenation strategies.Experimental & molecular medicine · 2026Review
- Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions.Nature aging · 2026Article
- Hematopoietic (stem) cells-The elixir of life?FEBS letters · 2026Review
- Periodic Therapeutic Phlebotomy Mitigates Systemic Aging Phenotypes by Promoting Bone Marrow Function.Aging cell · 2026Article
- Impact of time-restricted feeding on metabolic health and adipose tissue metabolism in aged female mice with high-fat diet-induced obesity.The Journal of physiology · 2026Article
- Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions.Aging cell · 2026Review
- Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Advances in Adipose Tissue Biology.Endocrine reviews · 2026Review
- Lessons in longevity from blood stem cells under protein stress.Trends in cell biology · 2026Review
- Energy's long game: thermogenic adipocytes and the metabolic diseases of modern life.Academia biology · 2026Article
- Influenza A infection accelerates disease-associated microglia formation during physiological aging.bioRxiv : the preprint server for biology · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 15 institutions in 6 countries.
Róbert Pálovics *Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Andreas Keller *Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. ackeller@stanford.edu.ORCID http://orcid.org/0000-0002-5361-0895
Nicholas Schaum *Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Weilun Tan *Chan Zuckerberg Biohub, San Francisco, CA, USA.
Tobias FehlmannClinical Bioinformatics, Saarland University, Saarbrücken, Germany.ORCID http://orcid.org/0000-0003-1967-2918
Michael BorjaChan Zuckerberg Biohub, San Francisco, CA, USA.
Fabian KernClinical Bioinformatics, Saarland University, Saarbrücken, Germany.ORCID http://orcid.org/0000-0002-8223-3750
Liana BonannoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Kruti CalcuttawalaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
James WebberChan Zuckerberg Biohub, San Francisco, CA, USA.
Aaron McGeeverChan Zuckerberg Biohub, San Francisco, CA, USA.
Tabula Muris Consortium
Jian LuoVeterans Administration Palo Alto Healthcare System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-2064-8467
Angela Oliveira PiscoChan Zuckerberg Biohub, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0142-2355
Jim KarkaniasChan Zuckerberg Biohub, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8057-6055
Norma F NeffChan Zuckerberg Biohub, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7141-5420
Spyros DarmanisChan Zuckerberg Biohub, San Francisco, CA, USA. spyros.darmanis@czbiohub.org.
Stephen R QuakeChan Zuckerberg Biohub, San Francisco, CA, USA. steve@quake-lab.org.ORCID http://orcid.org/0000-0002-1613-0809
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. twc@stanford.edu.ORCID http://orcid.org/0000-0001-5893-0831
Stanford University · USChan Zuckerberg Initiative (United States) · USUniversity of California, San Francisco · USCardiovascular Institute of the South · USNeurosciences Institute · USSaarland University · DEStanford Medicine · USVA Palo Alto Health Care System · USAarhus University · DKCanadian Institute for Advanced Research · CAHarvard University · USJagiellonian University · PLPalo Alto University · USPrincess Máxima Center · NLUniversity of Pittsburgh · US
Funding
Wnt signaling in muscle stem cell agingP01AG036695 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMAS A. RANDO · 2011 to 2026
$29.3MStanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI Jennifer Kaci Fairchild · 2020 to 2026
$29.0MStanford Medicine Center for Longevity and Healthy Aging Research Education CoreP30AG059307 · NIA · STANFORD UNIVERSITY · PI ZOU, JAMES · 2018 to 2025
$4.9MMicroglial lipid droplets in Alzheimer's diseaseRF1AG064928 · NIA · STANFORD UNIVERSITY · PI WYSS-CORAY, TONY · 2019 to 2019
$3.7MA Bioorthogonal Approach to Study Mammalian AgingDP1AG053015 · NIA · STANFORD UNIVERSITY · PI WYSS-CORAY, TONY · 2015 to 2019
$3.7MDefining the cellular and molecular mechanisms driving neointimal lesion growth in pulmonary hypertensionR01HL163013 · NHLBI · STANFORD UNIVERSITY · PI KUMAR, MAYA ELISE · 2022 to 2025
$2.7MMolecular signature of parabiosisR01AG072255 · NIA · STANFORD UNIVERSITY · PI WYSS-CORAY, TONY · 2021 to 2025
$2.4MCirculatory Rejuvenating Factors for the BrainR01AG045034 · NIA · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI WYSS-CORAY, TONY · 2013 to 2017
$1.4MReverse Engineering the Alveolus: From cellular to microenvironment specification during developmentR00HL127267 · NHLBI · MAYO CLINIC ROCHESTER · PI BROWNFIELD, DOUGLAS GLENN · 2019 to 2021
$747kBLR&D Research Career Scientist Award ApplicationIK6BX004599 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI WYSS-CORAY, TONY · 2019 to 2020
–BLRD VA IK6 BX004599NHLBI NIH HHS R00 HL127267NHLBI NIH HHS R01 HL163013NIA NIH HHS DP1 AG053015NIA NIH HHS P30 AG059307NIA NIH HHS P30 AG066515NIA NIH HHS R01 AG045034NIA NIH HHS R01 AG072255NIA NIH HHS RF1 AG064928NIH HHS R01 AG064928
Abstract
The ability to slow or reverse biological ageing would have major implications for mitigating disease risk and maintaining vitality
Indexed as
ParabiosisSingle-Cell AnalysisAdipocytesAgingElectron TransportHematopoietic Stem CellsHepatocytesMesenchymal Stem CellsMitochondriaOrgan SpecificityRejuvenationRNA-Seq
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.