Evidence map›Paper›PMID 35236972›Full record

ArticleNature2022

Biocatalytic oxidative cross-coupling reactions for biaryl bond formation.

Lara E Zetzsche, Jessica A Yazarians, Suman Chakrabarty, Meagan E Hinze, Lauren A M Murray, April L Lukowski, Leo A Joyce, Alison R H Narayan

Abstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

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  7. Photoenzymatic CspProceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lara E Zetzsche *Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-1644-7769
Jessica A Yazarians *Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-8129-8483
Suman ChakrabartyLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6611-3839
Meagan E HinzeLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-4448-058X
Lauren A M MurrayLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-3249-0828
April L LukowskiLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Leo A JoyceArrowhead Pharmaceuticals, Inc., Madison, WI, USA.ORCID http://orcid.org/0000-0002-8649-4894
Alison R H NarayanLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA. arhardin@umich.edu.ORCID http://orcid.org/0000-0001-8290-0077

Funding

Undergrad Supplement: Expanding the synthetic utility of natural product biosynthetic enzymesR35GM124880 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alison Narayan · 2017 to 2026
$4.5M
Cellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6M
Biocatalytic generation of bioactive biaryl natural productsF31AT010973 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZETZSCHE, LARA EMILY · 2020 to 2022
$81k
Biocatalytic approaches to antiepileptic drug targetsF31NS111906 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUKOWSKI, APRIL · 2019 to 2020
$49k
NCCIH NIH HHS F31 AT010973NIGMS NIH HHS R35 GM124880NIGMS NIH HHS T32 GM145304NINDS NIH HHS F31 NS111906
6 · The paper itself

Abstract

Biaryl compounds, with two connected aromatic rings, are found across medicine, materials science and asymmetric catalysis

Indexed as

BiocatalysisChemistry Techniques, SyntheticCarbonCoumarinsCytochrome P-450 Enzyme SystemHydrogenOxidantsOxidation-ReductionSubstrate SpecificityCarbonCoumarinsCytochrome P-450 Enzyme SystemHydrogenOxidants

Identifiers

PMID35236972
PMCPMC9213091

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.