ReviewMolecular psychiatry2022
The gut microbiome and mental health: advances in research and emerging priorities.
Review in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Potential gut-brain axis-targeted therapies for autism spectrum disorder in children: opportunities and challenges.World journal of pediatrics : WJP · 2025Pooled it
- The interactions between host genome and gut microbiome increase the risk of psychiatric disorders: Mendelian randomization and biological annotation.Brain, behavior, and immunity · 2023Pooled it
- Probiotic-mediated modulation of gut microbiome in students exposed to academic stress: a randomized controlled trial.NPJ biofilms and microbiomes · 2025Trial
- Synbiotic supplementation may globally improve non-motor symptoms in patients with stable Parkinson's disease: results from an open label single-arm study.Scientific reports · 2024Trial
- Synbiotic as an ameliorating factor in the health-related quality of life in women with polycystic ovary syndrome. A randomized, triple-blind, placebo-controlled trial.BMC women's health · 2024Trial
- Article
- Probiotics as Modulators of Adult Neurogenesis and Synaptic Plasticity: New Perspectives in the Pathophysiology and Treatment of Affective Disorders.Biomedicines · 2026Review
- Evaluating the analytical performance of direct-to-consumer gut microbiome testing services.Communications biology · 2026Article
- Review
- Modulating drug response through the gut microbiome: pathways to precision therapy.Archives of microbiology · 2026Review
- Development of a novel humanized gut-brain axis model as a tool toward personalized nutrition.Communications biology · 2026Article
- Gut Microbiome Care as a Gateway to Mental Well-being and Theological Restoration.Journal of religion and health · 2026Article
- Behavioral and human-computer interaction requirements for a candidate abdominal-sound-enabled dietary self-regulation system: a two-phase study in Taiwanese university students.Frontiers in nutrition · 2026Article
- Metabolomic and gut microbial biomarkers of smoking cessation treatment in long-term drug therapy: a study protocol for a randomized controlled trial.Frontiers in psychiatry · 2026Article
- Beyond the 'second brain': the gut microbiota as a constitutive co-constructor of embodied cognitive network.Frontiers in neuroscience · 2026Review
- TheMicrobiology and molecular biology reviews : MMBR · 2025Review
- Perinatal Shifts in Fecal-Derived Metabolites and Associations with Postpartum Depression.bioRxiv : the preprint server for biology · 2025Article
- An interoceptive model of energy allostasis linking metabolic and mental health.Science advances · 2025Review
- Understanding the Variability of Associations Between Higher Ultra-Processed Food Consumption and Self-Reported Depression Severity: A Systematic Review of Epidemiological Studies.Healthcare (Basel, Switzerland) · 2025Review
- Cross-sectional study of the association between nutrition and depression in older people living in nursing homes.BMC geriatrics · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiome exerts a considerable influence on human neurophysiology and mental health. Interactions between intestinal microbiology and host regulatory systems have now been implicated both in the development of psychiatric conditions and in the efficacy of many common therapies. With the growing acceptance of the role played by the gut microbiome in mental health outcomes, the focus of research is now beginning to shift from identifying relationships between intestinal microbiology and pathophysiology, and towards using this newfound insight to improve clinical outcomes. Here, we review recent advances in our understanding of gut microbiome-brain interactions, the mechanistic underpinnings of these relationships, and the ongoing challenge of distinguishing association and causation. We set out an overarching model of the evolution of microbiome-CNS interaction and examine how a growing knowledge of these complex systems can be used to determine disease susceptibility and reduce risk in a targeted manner.
Indexed as
Identifiers
35236957What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.