ArticleScientific reports2022
Development of a one-step analysis method for several amino acids using a microfluidic paper-based analytical device.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- NMR-Based Quantification of Collagen Content in Protein Hydrolysates.Journal of agricultural and food chemistry · 2026Article
- Challenges in the development of microfluidic paper-based analytical devices (μPADs).Mikrochimica acta · 2025Review
- Dual Chromatic Laser-Printed Microfluidic Paper-Based Analytical Device (μPAD) for the Detection of Atrazine in Water.ACS omega · 2023Article
- Adaptive time modulation technique for multiplexed on-chip particle detection across scales.Optica · 2023Article
- Machine learning at the edge for AI-enabled multiplexed pathogen detection.Scientific reports · 2023Article
- Biomedical Applications of Microfluidic Devices: A Review.Biosensors · 2022Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A one-step analysis method was developed for four types of amino acids using a microfluidic paper-based analytical device fabricated from chromatography filtration paper and laminate films. Aminoacyl-tRNA synthetase was used to detect each amino acid. The obtained laminated paper-based analytical device (LPAD) contained four enzymatic reaction areas. Colorimetric detection was performed based on the molybdenum blue reaction. A model method for the simple, easy, and simultaneous detection of several amino acid concentrations was suggested, in contrast to the conventional methods such as HPLC or LC-MS. The method provided a selective quantification at the ranges of 3.6-100 μM for tryptophan, 10.1-100 μM for glycine, 5.9-100 μM for histidine and 5.6-100 μM for lysine with a detection limit of 1.1 μM, 3.3 μM, 1.9 μM and 1.8 μM, respectively. LPAD fabrication was considerably simple, and the subsequent detection process was easy and required a short period of time (within 15 min).
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