Evidence map›Paper›PMID 35236763›Full record

Trial reportThorax2022

Routine lung volume recruitment in boys with Duchenne muscular dystrophy: a randomised clinical trial.

Sherri L Katz, Jean K Mah, Hugh J McMillan, Craig Campbell, Vid Bijelić, Nick Barrowman, Franco Momoli, Henrietta Blinder, Shawn D Aaron, Laura C McAdam and 9 more

2 registry-linked trialsOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Thorax, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01999075 phase4completednot on this map

Stacking Exercises Attenuate the Decline in Forced Vital Capacity and Sick Time (STEADFAST)

TypeinterventionalSponsorChildren's Hospital of Eastern OntarioRan2013 to 2018Enrolled70ConditionsDuchenne Muscular DystrophyArmsLung Volume Recruitment (LVR), Conventional Treatment
NCT06119087 nacompletednot on this mapstarted 2024, after this paper: background citation

Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study

TypeinterventionalSponsorUniversity of PennsylvaniaRan2024 to 2026Enrolled23ConditionsAmyotrophic Lateral Sclerosis, Chronic Respiratory Failure, Airway Clearance Impairment, Neuromuscular DiseasesArmsMechanical insufflation
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. [Screening for Duchenne muscular dystrophy in newborns in the Ningxia region].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 4 countries.

Sherri L KatzDepartment of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada skatz@cheo.on.ca.
Jean K MahDivision of Pediatric Neurology, Alberta Children's Hospital, Calgary, Alberta, Canada.
Hugh J McMillanDepartment of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Craig CampbellDepartment of Pediatrics, Epidemiology and Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada.
Vid BijelićCHEO Research Institute, Ottawa, Ontario, Canada.
Nick BarrowmanCHEO Research Institute, Ottawa, Ontario, Canada.
Franco MomoliFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Henrietta BlinderCHEO Research Institute, Ottawa, Ontario, Canada.ORCID 0000-0001-6307-6094
Shawn D AaronFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Laura C McAdamHolland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
The Thanh Diem NguyenDepartment of Respiratory Medicine, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada.
Mark TarnopolskyDivision of Neuromuscular and Neurometabolic Disease, McMaster University, Hamilton, Ontario, Canada.
David F WensleyDivision of Pediatric Respirology, Department of Pediatrics, BC Children's Hospital, Vancouver, British Columbia, Canada.
David ZielinskiDivision of Pediatric Respirology, Department of Pediatrics, Montreal Children's Hospital, Montreal, Quebec, Canada.
Louise RoseDepartment of Midwifery and Palliative Care, King's College London Florence Nightingale School of Nursing and Midwifery, London, London, UK.
Nicole SheersDepartment of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia.ORCID 0000-0003-1847-4266
David J BerlowitzDepartment of Respiratory and Sleep Medicine, Institute for Breathing and Sleep, Heidelberg, Victoria, Australia.ORCID 0000-0003-2543-8722
Lisa WolfeDepartment of Medicine and Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Doug McKimFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
University of Ottawa · CAAgricultural Research Institute of Ontario · CAThe University of Melbourne · AUCentre Hospitalier Universitaire Sainte-Justine · CAKing's College London · GBMcMaster University · CAMontreal Children's Hospital · CANorthwestern University · USUniversity of British Columbia · CAUniversity of Calgary · CAUniversity of Toronto · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImpaired cough results in airway secretion retention, atelectasis and pneumonia in individuals with Duchenne muscular dystrophy (DMD). Lung volume recruitment (LVR) stacks breaths to inflate the lungs to greater volumes than spontaneous effort. LVR is recommended in DMD clinical care guidelines but is not well studied. We aimed to determine whether twice-daily LVR, compared with standard of care alone, attenuates the decline in FVC at 2 years in boys with DMD.

methodsIn this multicentre, assessor-blinded, randomised controlled trial, boys with DMD, aged 6-16 years with FVC >30% predicted, were randomised to receive conventional treatment or conventional treatment plus manual LVR twice daily for 2 years. The primary outcome was FVC % predicted at 2 years, adjusted for baseline FVC % predicted, age and ambulatory status. Secondary outcomes included change in chest wall distensibility (maximal insufflation capacity minus FVC) and peak cough flow.

resultsSixty-six boys (36 in LVR group, 30 in control) were evaluated (median age (IQR): 11.5 years (9.5-13.5), median baseline FVC (IQR): 85% predicted (73-96)). Adjusted mean difference in FVC between groups at 2 years was 1.9% predicted (95% CI -6.9% to 10.7%; p=0.68) in the direction of treatment benefit. We found no differences in secondary outcomes.

conclusionThere was no difference in decline in FVC % predicted with use of twice-daily LVR for boys with DMD and relatively normal lung function. The burden associated with routine LVR may outweigh the benefit. Benefits of LVR to maintain lung health in boys with worse baseline lung function still need to be clarified. TRIAL REGISTRATION NUMBER: NCT01999075.

Indexed as

Muscular Dystrophy, DuchenneCoughHumansLung Volume MeasurementsMaleRespiratory Function TestsVital CapacitychildDuchenne muscular dystrophylung volume recruitmentrandomized controlled trialrespiratory therapy

Identifiers

PMID35236763
PMCPMC9340020
OpenAlexW4214900636

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.