Evidence map›Paper›PMID 35236423›Full record

Trial reportJournal of health, population, and nutrition2022

Efficacy of low-fat milk and yogurt fortified with vitamin D

Payam Sharifan, Mohammad Rashidmayvan, Zahra Khorasanchi, Susan Darroudi, Azam Heidari, Fatemeh Hoseinpoor, Hassan Vatanparast, Mohamad Safarian, Saeid Eslami, Asma Afshari and 7 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of health, population, and nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 4 countries.

Payam Sharifan *Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad Rashidmayvan *Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Zahra KhorasanchiStudent Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Susan DarroudiInternational UNESCO Center for Health Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, 99199-91766, Mashhad, Iran.
Azam HeidariDepartment of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
Fatemeh HoseinpoorDepartment of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
Hassan VatanparastCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.
Mohamad SafarianDepartment of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Saeid EslamiDepartment of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Asma AfshariDepartment of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Zahra AsadiInternational UNESCO Center for Health Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, 99199-91766, Mashhad, Iran.
Hamideh GhazizadehStudent Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad BagherniyaDepartment of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Hamed KhedmatgozarDepartment of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Gordon FernsDivision of Medical Education, Brighton and Sussex Medical School, Brighton, UK.
Mitra Rezaie *Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. rezaeim1@mums.ac.ir.
Majid Ghayour Mobarhan *Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. ghayourm@mums.ac.ir.
Mashhad University of Medical Sciences · IRBrighton and Sussex Medical School · GBIsfahan University of Medical Sciences · IRTexas Tech University · USUniversity of Saskatchewan · CAVarastegan Institute for Medical Sciences

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of vitamin D deficiency is increasing globally and is associated with an increased risk of metabolic syndrome, autoimmune disease, and cardiovascular disease. Vit D deficiency is also associated with increased systemic inflammation. The current study aimed to determine the efficacy of low-fat milk and yogurt fortified with 1500 IU nano-encapsulated vitamin D, on systemic inflammation in abdominal obese participants.

methodThis multi-center study was conducted using a 2.5-month parallel total-blind randomized clinical trial design. Two hundred and eighty nine subjects were allocated to four groups: low-fat milk fortified by 1500 IU nano-encapsulated vitamin D

resultsThe results showed that serum levels of neutrophils, lymphocytes, platelets and red blood cell distribution width (RDW) were significantly lower before and after the intervention in fortified dairy groups. The results showed that serum levels of neutrophils, lymphocytes, platelets, and RDW before and after intervention in the fortified dairy groups were significantly lower (p < 0.05). The values of = neutrophil to lymphocyte ratio (NLR), platelets to lymphocyte ratio, and RDW to platelets ratio (RPR) reduced significantly in the fortification group (p < 0.05).

conclusionFortification with nano-encapsulated vitamin D

Indexed as

CholecalciferolVitamin D DeficiencyAdultAnimalsFood, FortifiedHumansInflammationMilkObesity, AbdominalVitamin DYogurtCholecalciferolVitamin DFortificationInflammationLow-fat dairyObesityVitamin D

Identifiers

PMID35236423
PMCPMC8889656
OpenAlexW4214898972

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.