ArticleOrphanet journal of rare diseases2022
Age-dependent oral manifestations of neurofibromatosis type 1: a case-control study.
Article in Orphanet journal of rare diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Higher caries experience in individuals with neurofibromatosis 1: a matched case-control study.Clinical oral investigations · 2026Article
- Endometriosis and Sjögren's syndrome: Bidirectional associations in population-based 15-year retrospective cohorts.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Dental Developmental Stages and Decayed, Missing, and Restored Teeth in Neurofibromatosis Type 1-affected Children and Adolescents.Journal of clinical and experimental dentistry · 2024Article
- Importance of Metalloproteinase 8 (MMP-8) in the Diagnosis of Periodontitis.International journal of molecular sciences · 2024Review
- The Role of Interleukin 6 in Periodontitis and Its Complications.International journal of molecular sciences · 2024Review
- Domiciliary Dental Care for Medically Compromised Patients in Aging and Super-aged Societies: Policy and Education.Aging and disease · 2023Article
- Bromelain inhibits the inflammation and senescence effect in diabetic periodontitis: A preliminaryJournal of dental sciences · 2023Article
- Bidirectional Relationship Between Osteoarthritis and Periodontitis: A Population-Based Cohort Study Over a 15-year Follow-Up.Frontiers in immunology · 2022Article
- Exposure to environmental air pollutants as a risk factor for primary Sjögren's syndrome.Frontiers in immunology · 2022Article
- Risk of primary Sjogren's Syndrome following human papillomavirus infections: a nationwide population-based cohort study.Frontiers in immunology · 2022Article
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMost craniofacial manifestations of neurofibromatosis type 1 (NF1) are considered as a result of tumor compression. We sought to determine salivary changes, caries, and periodontal complications in NF1 patients without tumors in the oral cavity. OBJECTIVE AND
methodsEleven NF1 patients without tumors in the oral cavity and 29 matched controls without NF1 were enrolled in this case-control study. Demographic information, medical history, and data of intraoral examinations, including the Decayed, Missing, and Filled Teeth (DMFT) scores and Russel's periodontal index (PI), were recorded. The functional salivary analysis was performed for sialometry, salivary pH values, and amylase activity. Ingenuity Systems Pathway Analysis (IPA) was conducted to identify mutually activated pathways for NF1-associated oral complications.
resultsNF1 patients were associated with periodontitis (OR = 1.40, 95% CI = 1.06-1.73, P = 0.04), gingivitis (OR = 1.55, 95% CI = 1.09-2.01, P = 0.0002), and decreased salivary flow rates (OR = 1.40, 95% CI = 1.05-1.76, P = 0.005). Periodontal destruction, salivary changes, and dental caries in NF1 patients were age-dependent. Subgroup analyses based on age stratification suggested that salivary flow rates and salivary amylase activities were significantly low in NF1 patients aged over 20 years and that salivary pH values, PI and DMFT scores were significantly high among NF1- controls aged over 20. All oral complications were not significantly presented in NF1 patients aged below 20 years. IPA analyses suggested that cellular mechanisms underlying NF1-associated oral complications involved chronic inflammatory pathways and fibrosis signaling pathway.
conclusionNF1 patients without tumors in the oral cavity presented a comparatively high prevalence of age-dependent oral complications, including periodontal destruction and salivary gland dysfunction, which were associated with chronic inflammatory pathogenesis.
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