Evidence map›Paper›PMID 35236255›Full record

ArticleBioengineered2022

MicroRNA-137 inhibits the inflammatory response and extracellular matrix degradation in lipopolysaccharide-stimulated human nucleus pulposus cells by targeting activin a receptor type I.

Bin Yu, Ziqi Zhu, Beiduo Shen, Jiawei Lu, Kai Guo, Weidong Zhao, Desheng Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bin YuDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Ziqi ZhuDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Beiduo ShenDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiawei LuDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Kai GuoDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Weidong ZhaoDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Desheng WuDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Shanghai East Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the role played by microRNA (miR)-137 in intervertebral disc degeneration via targeting activin A receptor type I (ACVR1) and the underlying mechanism. Human nucleus pulposus cells were exposed to 10 ng/mL lipopolysaccharide (LPS) to establish an

Indexed as

Intervertebral Disc DegenerationMicroRNAsNucleus PulposusActivin Receptors, Type IActivinsAggrecansApoptosisCells, CulturedCollagen Type IIExtracellular MatrixHumansLipopolysaccharidesactivin AActivin Receptors, Type IActivinsACVR1 protein, humanAggrecansCollagen Type IILipopolysaccharidesMicroRNAsMIRN137 microRNA, humanACVR1intervertebral disc degenerationlipopolysaccharidemicroRNA-137

Identifiers

PMID35236255
PMCPMC8973860
OpenAlexW4214851677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.