ArticleThe American journal of psychiatry2022
Genetics and Brain Transcriptomics of Completed Suicide.
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Article in The American journal of psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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28citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 4% of its field
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Gene expression meta-analysis in the prefrontal cortex: unraveling biological underpinnings of suicidal risk.BMC psychiatry · 2026Pooled it
- Identification of suicide brain transcriptomic signatures using meta-analysis of multiple cohorts.Translational psychiatry · 2026Pooled it
- Glial Markers of Suicidal Behavior in the Human Brain-A Systematic Review of Postmortem Studies.International journal of molecular sciences · 2024Pooled it
- In the Search for Suicide Signatures, Phenotype Matters.Translational psychiatry · 2026Article
- Pursuing the elusive biosignature for suicide: a decennial update.Molecular psychiatry · 2026Review
- Thalamocortical functional connectivity alterations and peripheral immune transcriptomic dysregulation in major depressive disorder patients with suicidal ideation.Translational psychiatry · 2026Article
- Astrocyte fatty acid metabolism as a driver of risk for major depressive disorder.Nature communications · 2026Article
- From Bacillus Criminalis to the Legalome: Will Neuromicrobiology Impact 21st Century Criminal Justice?Brain sciences · 2025Article
- MNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Deconvolution-Based Transcriptomic Analysis in the Hippocampus Reveals Cell Type-Specific Risk Genes and Pathways Associated With Depression and Suicide.Biological psychiatry global open science · 2025Article
- Multi-Omics Analysis Reveals Disturbances of Purine Metabolism and Glutamate Metabolism in the Hippocampus of Lipopolysaccharide-Induced Mouse Model of Depression.Brain and behavior · 2025Article
- Aggression and Justice Involvement: Does Uric Acid Play a Role?Brain sciences · 2025Article
- Purinergic System Transcript Changes in the Dorsolateral Prefrontal Cortex in Suicide and Major Depressive Disorder.International journal of molecular sciences · 2025Article
- Prenatal opioid exposure alters pain perception and increases long-term health risks in infants with neonatal opioid withdrawal syndrome.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Omics Approaches to Investigate the Pathogenesis of Suicide.Biological psychiatry · 2024Review
- Reverse phase protein array-based investigation of mitochondrial genes reveals alteration of glutaminolysis in the parahippocampal cortex of people who died by suicide.Translational psychiatry · 2024Article
- Alcohol use disorder and risk of specific methods of suicide death in a national cohort.Acta psychiatrica Scandinavica · 2024Article
- Homicide or Happiness: Did Folate Fortification and Public Health Campaigns Influence Homicide Rates and the Great American Crime Decline?Nutrients · 2024Article
- Impact ofJournal of clinical medicine · 2024Review
- Prenatal opioid exposure significantly impacts placental protein kinase C (PKC) and drug transporters, leading to drug resistance and neonatal opioid withdrawal syndrome.Frontiers in neuroscience · 2024Article
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Authors and funding
15 authors at 1 institution in 1 country.
Giovanna PunziLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore (Punzi, Ursini, Chen, Radulescu, Tao, Huuki, Di Carlo, Collado-Torres, Shin, Jaffe, Hyde, Kleinman, Weinberger); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Ursini, Hyde, Kleinman, Weinberger); Section of Forensic Psychiatry and Criminology, Institute of Legal Medicine, D.I.M., University of Bari "Aldo Moro," Bari, Italy (Catanesi); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde, Weinberger); Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, S.C. (Mackay); Departments of Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (Weinberger).
Gianluca UrsiniLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore (Punzi, Ursini, Chen, Radulescu, Tao, Huuki, Di Carlo, Collado-Torres, Shin, Jaffe, Hyde, Kleinman, Weinberger); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Ursini, Hyde, Kleinman, Weinberger); Section of Forensic Psychiatry and Criminology, Institute of Legal Medicine, D.I.M., University of Bari "Aldo Moro," Bari, Italy (Catanesi); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde, Weinberger); Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, S.C. (Mackay); Departments of Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (Weinberger).
Qiang ChenLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore (Punzi, Ursini, Chen, Radulescu, Tao, Huuki, Di Carlo, Collado-Torres, Shin, Jaffe, Hyde, Kleinman, Weinberger); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Ursini, Hyde, Kleinman, Weinberger); Section of Forensic Psychiatry and Criminology, Institute of Legal Medicine, D.I.M., University of Bari "Aldo Moro," Bari, Italy (Catanesi); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde, Weinberger); Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, S.C. (Mackay); Departments of Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (Weinberger).
Eugenia RadulescuLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore (Punzi, Ursini, Chen, Radulescu, Tao, Huuki, Di Carlo, Collado-Torres, Shin, Jaffe, Hyde, Kleinman, Weinberger); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Ursini, Hyde, Kleinman, Weinberger); Section of Forensic Psychiatry and Criminology, Institute of Legal Medicine, D.I.M., University of Bari "Aldo Moro," Bari, Italy (Catanesi); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde, Weinberger); Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, S.C. (Mackay); Departments of Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (Weinberger).
Ran TaoLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore (Punzi, Ursini, Chen, Radulescu, Tao, Huuki, Di Carlo, Collado-Torres, Shin, Jaffe, Hyde, Kleinman, Weinberger); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Ursini, Hyde, Kleinman, Weinberger); Section of Forensic Psychiatry and Criminology, Institute of Legal Medicine, D.I.M., University of Bari "Aldo Moro," Bari, Italy (Catanesi); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde, Weinberger); Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, S.C. (Mackay); Departments of Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (Weinberger).
Louise A HuukiLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore (Punzi, Ursini, Chen, Radulescu, Tao, Huuki, Di Carlo, Collado-Torres, Shin, Jaffe, Hyde, Kleinman, Weinberger); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Ursini, Hyde, Kleinman, Weinberger); Section of Forensic Psychiatry and Criminology, Institute of Legal Medicine, D.I.M., University of Bari "Aldo Moro," Bari, Italy (Catanesi); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde, Weinberger); Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, S.C. (Mackay); Departments of Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (Weinberger).
Pasquale Di CarloLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore (Punzi, Ursini, Chen, Radulescu, Tao, Huuki, Di Carlo, Collado-Torres, Shin, Jaffe, Hyde, Kleinman, Weinberger); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Ursini, Hyde, Kleinman, Weinberger); Section of Forensic Psychiatry and Criminology, Institute of Legal Medicine, D.I.M., University of Bari "Aldo Moro," Bari, Italy (Catanesi); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde, Weinberger); Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, S.C. (Mackay); Departments of Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (Weinberger).
Leonardo Collado-TorresLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore (Punzi, Ursini, Chen, Radulescu, Tao, Huuki, Di Carlo, Collado-Torres, Shin, Jaffe, Hyde, Kleinman, Weinberger); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Ursini, Hyde, Kleinman, Weinberger); Section of Forensic Psychiatry and Criminology, Institute of Legal Medicine, D.I.M., University of Bari "Aldo Moro," Bari, Italy (Catanesi); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde, Weinberger); Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, S.C. (Mackay); Departments of Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (Weinberger).
Joo Heon ShinLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore (Punzi, Ursini, Chen, Radulescu, Tao, Huuki, Di Carlo, Collado-Torres, Shin, Jaffe, Hyde, Kleinman, Weinberger); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Ursini, Hyde, Kleinman, Weinberger); Section of Forensic Psychiatry and Criminology, Institute of Legal Medicine, D.I.M., University of Bari "Aldo Moro," Bari, Italy (Catanesi); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde, Weinberger); Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, S.C. (Mackay); Departments of Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (Weinberger).
Roberto CatanesiLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore (Punzi, Ursini, Chen, Radulescu, Tao, Huuki, Di Carlo, Collado-Torres, Shin, Jaffe, Hyde, Kleinman, Weinberger); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Ursini, Hyde, Kleinman, Weinberger); Section of Forensic Psychiatry and Criminology, Institute of Legal Medicine, D.I.M., University of Bari "Aldo Moro," Bari, Italy (Catanesi); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde, Weinberger); Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, S.C. (Mackay); Departments of Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (Weinberger).
Andrew E JaffeLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore (Punzi, Ursini, Chen, Radulescu, Tao, Huuki, Di Carlo, Collado-Torres, Shin, Jaffe, Hyde, Kleinman, Weinberger); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Ursini, Hyde, Kleinman, Weinberger); Section of Forensic Psychiatry and Criminology, Institute of Legal Medicine, D.I.M., University of Bari "Aldo Moro," Bari, Italy (Catanesi); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde, Weinberger); Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, S.C. (Mackay); Departments of Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (Weinberger).
Thomas M HydeLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore (Punzi, Ursini, Chen, Radulescu, Tao, Huuki, Di Carlo, Collado-Torres, Shin, Jaffe, Hyde, Kleinman, Weinberger); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Ursini, Hyde, Kleinman, Weinberger); Section of Forensic Psychiatry and Criminology, Institute of Legal Medicine, D.I.M., University of Bari "Aldo Moro," Bari, Italy (Catanesi); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde, Weinberger); Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, S.C. (Mackay); Departments of Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (Weinberger).
Joel E KleinmanLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore (Punzi, Ursini, Chen, Radulescu, Tao, Huuki, Di Carlo, Collado-Torres, Shin, Jaffe, Hyde, Kleinman, Weinberger); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Ursini, Hyde, Kleinman, Weinberger); Section of Forensic Psychiatry and Criminology, Institute of Legal Medicine, D.I.M., University of Bari "Aldo Moro," Bari, Italy (Catanesi); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde, Weinberger); Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, S.C. (Mackay); Departments of Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (Weinberger).
Trudy F C MackayLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore (Punzi, Ursini, Chen, Radulescu, Tao, Huuki, Di Carlo, Collado-Torres, Shin, Jaffe, Hyde, Kleinman, Weinberger); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Ursini, Hyde, Kleinman, Weinberger); Section of Forensic Psychiatry and Criminology, Institute of Legal Medicine, D.I.M., University of Bari "Aldo Moro," Bari, Italy (Catanesi); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde, Weinberger); Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, S.C. (Mackay); Departments of Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (Weinberger).
Daniel R WeinbergerLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore (Punzi, Ursini, Chen, Radulescu, Tao, Huuki, Di Carlo, Collado-Torres, Shin, Jaffe, Hyde, Kleinman, Weinberger); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Ursini, Hyde, Kleinman, Weinberger); Section of Forensic Psychiatry and Criminology, Institute of Legal Medicine, D.I.M., University of Bari "Aldo Moro," Bari, Italy (Catanesi); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde, Weinberger); Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, S.C. (Mackay); Departments of Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (Weinberger).
Johns Hopkins University · US
Funding
Decomposing cell type-specific marks in post-mortem human brain studiesR21MH105853 · NIMH · LIEBER INSTITUTE, INC. · PI JAFFE, ANDREW ELLIS, WEINBERGER, DANIEL · 2015 to 2016
$509kNIMH NIH HHS R21 MH105853
Abstract
objectiveThe authors sought to study the transcriptomic and genomic features of completed suicide by parsing the method chosen, to capture molecular correlates of the distinctive frame of mind of individuals who die by suicide, while reducing heterogeneity.
methodsThe authors analyzed gene expression (RNA sequencing) from postmortem dorsolateral prefrontal cortex of patients who died by suicide with violent compared with nonviolent means, nonsuicide patients with the same psychiatric disorders, and a neurotypical group (total N=329). They then examined genomic risk scores (GRSs) for each psychiatric disorder included, and GRSs for cognition (IQ) and for suicide attempt, testing how they predict diagnosis or traits (total N=888).
resultsPatients who died by suicide by violent means showed a transcriptomic pattern remarkably divergent from each of the other patient groups but less from the neurotypical group; consistently, their genomic profile of risk was relatively low for their diagnosed illness as well as for suicide attempt, and relatively high for IQ: they were more similar to the neurotypical group than to other patients. Differentially expressed genes (DEGs) associated with patients who died by suicide by violent means pointed to purinergic signaling in microglia, showing similarities to a genome-wide association study of
conclusionsThese findings suggest that patients who die by suicide by violent means are in part biologically separable from other patients with the same diagnoses, and their behavioral outcome may be less dependent on genetic risk for conventional psychiatric disorders and be associated with an alteration of purinergic signaling and mitochondrial metabolism.
Indexed as
Suicide, CompletedBrainGenome-Wide Association StudyHumansTranscriptomeViolenceGenomic RiskMitochondriaPostmortem BrainPurinergic SignalingRNA SequencingSuicide Method
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