ArticleCell reports2022
State-dependent olfactory processing in freely behaving mice.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Experience and behavior modulate piriform cortex odor representation in freely moving mice.iScience · 2026Article
- Respiratory pauses highlight sleep architecture in mice.Nature communications · 2026Article
- Adult-neurogenesis allows for representational stability and flexibility in early olfactory system.eLife · 2026Article
- A role for the thalamus in danger evoked awakening during sleep.Nature communications · 2025Article
- The Disputable Costs of Sleeping.Biology · 2025Review
- [Application of optogenetic technology in the research on olfactory bulb neural projection from advanced brain regions to regulate olfactory signal processing].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- Breathing orchestrates synchronization of sleep oscillations in the human hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Oxytocin induces the formation of distinctive cortical representations and cognitions biased toward familiar mice.Nature communications · 2024Article
- Glutamatergic neurons of piriform cortex delay induction of inhalational general anesthesia.Fundamental research · 2024Article
- Intranasal Pressure Recording for Monitoring Mouse Respiration.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Machine learning-based clustering and classification of mouse behaviors via respiratory patterns.iScience · 2022Article
- Reciprocal relationships between sleep and smell.Frontiers in neural circuits · 2022Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Decreased responsiveness to sensory stimuli during sleep is presumably mediated via thalamic gating. Without an obligatory thalamic relay in the olfactory system, the anterior piriform cortex (APC) is suggested to be a gate in anesthetized states. However, olfactory processing in natural sleep states remains undetermined. Here, we simultaneously record local field potentials (LFPs) in hierarchical olfactory regions (olfactory bulb [OB], APC, and orbitofrontal cortex) while optogenetically activating olfactory sensory neurons, ensuring consistent peripheral inputs across states in behaving mice. Surprisingly, evoked LFPs in sleep states (both non-rapid eye movement [NREM] and rapid eye movement [REM]) are larger and contain greater gamma-band power and cross-region coherence (compared to wakefulness) throughout the olfactory pathway, suggesting the lack of a central gate. Single-unit recordings from the OB and APC reveal a higher percentage of responsive neurons during sleep with a higher incidence of suppressed firing. Additionally, nasal breathing is slower and shallower during sleep, suggesting a partial peripheral gating mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.