ArticleCell reports2022
Interferon-γ promotes monocyte-mediated lung injury during influenza infection.
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Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
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Who cites it
53 citing papers in PubMed, 79 citations in OpenAlex.
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- Generation of an Induced Pluripotent Stem Cell-Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments.Advanced healthcare materials · 2026Article
- The ribosomal landscape in influenza A virus infection: from molecular mechanisms to clinical relevance.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- T-cell immunity against influenza virus does not require Th1 or Th17 master regulator transcription factors.Mucosal immunology · 2025Article
- Thyroid hormone receptor α signaling shapes innate and adaptive immune responses during viral infection.European thyroid journal · 2025Article
- High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures.Nature communications · 2025Article
- NF-κB driven inflammation mediates loss of upper airway epithelial tolerance tobioRxiv : the preprint server for biology · 2025Article
- Ninjurin-1 mediates cell lysis and detrimental inflammation of PANoptosis during influenza A virus infection.Signal transduction and targeted therapy · 2025Article
- The long reach of influenza and other respiratory viruses: from acute epithelial injury to post-viral lung disease.Clinical microbiology reviews · 2025Review
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- Virus-Induced Cellular Senescence Causes Pulmonary Sequelae Post-Influenza Infection.Aging cell · 2025Article
- Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Type I Interferon Targets Alveolar Macrophages to Promote Bacterial Pneumonia after Viral Infection.American journal of respiratory cell and molecular biology · 2025Article
- Serial Cross-Sectional Human Biomonitoring Analysis of Pesticide Exposure Patterns and Their Association with Lipid Metabolism Biomarkers: The Mediating Role of Liver Function.Environment & health (Washington, D.C.) · 2025Article
- Chimeric hemagglutinin and M2 mRNA vaccine for broad influenza subtype protection.NPJ vaccines · 2025Article
- TLR7 deficiency enhances inflammation in the URT but reduces LRT immunity following influenza A infection.Scientific reports · 2025Article
- The Role of TLR4 in Lung Epithelial Cell Injury Caused by Influenza Virus Combined withMicroorganisms · 2025Article
- ZBP1-driven cell death in severe influenza.Trends in microbiology · 2025Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Taylor SchmitDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Kai GuoDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.
Jitendra Kumar TripathiDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Zhihan WangWest China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
Brett McGregorDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Mitch KlompDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Ganesh AmbigapathyDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Ramkumar MathurDepartment of Geriatrics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Junguk HurDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Michael PichicheroRochester General Hospital Research Institute, 1425 Portland Avenue, Rochester, NY 14621, USA.
Jay KollsCenter for Translational Research in Infection and Inflammation, Department of Pediatrics and Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
M Nadeem KhanDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32603, USA. Electronic address: nkhan2@dental.ufl.edu.
University of North Dakota · USRochester General Hospital · USTulane University · USUniversity of Michigan · USWest China Medical Center of Sichuan University · CN
Funding
Research CoresP20GM103442 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI Donald A. Sens · 2012 to 2026
$53.0MTracking and Evaluation CoreU54GM128729 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI BASSON, MARC D. · 2018 to 2022
$20.3MYersina perstis interactions with macrophagesP20GM113123 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2016 to 2025
$19.9MPathogenic role of IL-17 response in Streptococcus pneumoniae nasopharyngeal pathogenesis during an influenza virus co-infectionR01AI143741 · NIAID · UNIVERSITY OF NORTH DAKOTA · PI KHAN, NADEEM · 2020 to 2024
$1.9MUtilization of the adjuvant effect of CRM197 protein to develop a trivalentprotein-vaccine against Streptococcus pneumoniae infectionsR21AI151522 · NIAID · UNIVERSITY OF NORTH DAKOTA · PI KHAN, NADEEM · 2021 to 2022
$402kNIAID NIH HHS R01 AI143741NIAID NIH HHS R21 AI151522NIGMS NIH HHS P20 GM103442NIGMS NIH HHS P20 GM113123NIGMS NIH HHS U54 GM128729
Abstract
Influenza A virus (IAV) infection triggers an exuberant host response that promotes acute lung injury. However, the host response factors that promote the development of a pathologic inflammatory response to IAV remain incompletely understood. In this study, we identify an interferon-γ (IFN-γ)-regulated subset of monocytes, CCR2
Indexed as
Influenza A virusInfluenza, HumanLung InjuryOrthomyxoviridae InfectionsAnimalsCD8-Positive T-LymphocytesHumansInterferon-gammaLungMiceMice, Inbred C57BLMice, KnockoutMonocytesInterferon-gammaacute lung injuryCCR2(+) monocyteinfluenzainterferon-γsingle-cell RNA sequencingStreptococcus pneumoniae
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.