ArticleCerebral cortex (New York, N.Y. : 1991)2023
The human vestibular cortex: functional anatomy of OP2, its connectivity and the effect of vestibular disease.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Neuroanatomical correlates of stroke-related dizziness and vertigo: secondary analysis from the INSPiRE-TMS trial.Journal of neurology · 2026Trial
- Intranasal drug delivery: Unlocking the nose-to-brain route for central nervous system therapies.International journal of pharmaceutics: X · 2026Review
- Imaging of vestibular function and disorders and its clinical relevance.Current opinion in neurology · 2026Review
- From balance to perception: vestibular-cognitive integration predicts signal discrimination in a Multirule Visual Monitoring Task.Frontiers in psychology · 2026Article
- Cortical vestibular-visual interactions and cross-modal plasticity-adaptive neural processes for stable perception.Frontiers in neural circuits · 2026Review
- Sensory network segregation as a predictor of post spaceflight balance impairments and sensory re-weighting.NPJ microgravity · 2025Article
- Associations Between Vestibular Function and White Matter Microstructure in Healthy Older Adults.medRxiv : the preprint server for health sciences · 2025Article
- Review
- The vestibular system in pain and embodiment: cortical overlap, modulatory potential, and therapeutic perspectives.Frontiers in neuroscience · 2025Article
- Article
- Daily artificial gravity partially mitigates vestibular processing changes associated with head-down tilt bedrest.NPJ microgravity · 2024Article
- Localization of Vestibular Cortex Using Electrical Cortical Stimulation: A Systematic Literature Review.Brain sciences · 2024Review
- Cognition in vestibular disorders: state of the field, challenges, and priorities for the future.Frontiers in neurology · 2024Review
- Innovative approaches for managing patients with chronic vestibular disorders: follow-up indicators and predictive markers for studying the vestibular error signal.Frontiers in rehabilitation sciences · 2024Article
- Top-down control of vestibular inputs by the dorsolateral prefrontal cortex.Experimental brain research · 2023Article
- Eagle-449: A volumetric, whole-brain compilation of brain atlases for vestibular functional MRI research.Scientific data · 2023Article
- Insufficiencies in sensory systems reweighting is associated with walking impairment severity in chronic stroke: an observational cohort study.Frontiers in neurology · 2023Article
- The brain-body disconnect: A somatic sensory basis for trauma-related disorders.Frontiers in neuroscience · 2022Review
- Patterns of vestibular dysfunction in chronic traumatic brain injury.Frontiers in neurology · 2022Article
- The connectome from the cerebral cortex to skeletal muscle using viral transneuronal tracers: a review.American journal of translational research · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Area OP2 in the posterior peri-sylvian cortex has been proposed to be the core human vestibular cortex. We investigated the functional anatomy of OP2 and adjacent areas (OP2+) using spatially constrained independent component analysis (ICA) of functional magnetic resonance imaging (fMRI) data from the Human Connectome Project. Ten ICA-derived subregions were identified. OP2+ responses to vestibular and visual motion were analyzed in 17 controls and 17 right-sided vestibular neuritis patients who had previously undergone caloric and optokinetic stimulation during fMRI. In controls, a posterior part of right OP2+ showed: (i) direction-selective responses to visual motion and (ii) activation during caloric stimulation that correlated positively with perceived self-motion, and negatively with visual dependence and peak slow-phase nystagmus velocity. Patients showed abnormal OP2+ activity, with an absence of visual or caloric activation of the healthy ear and no correlations with vertigo or visual dependence-despite normal slow-phase nystagmus responses to caloric stimulation. Activity in a lateral part of right OP2+ correlated with chronic visually induced dizziness in patients. In summary, distinct functional subregions of right OP2+ show strong connectivity to other vestibular areas and a profile of caloric and visual responses, suggesting a central role for vestibular function in health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.