ArticlePloS one2022
Effect of flow diverter stent malposition on intracranial aneurysm hemodynamics-An experimental framework using stereoscopic particle image velocimetry.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Comaneci stent-angioplasty for the optimization of inadequately deployed flow diverter stents.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Safety and efficacy of the pipeline vantage flow diverter in small cerebral vessels ≤2.5 mm: a case series.Neuroradiology · 2026Article
- A Proposed Grading Scale Based on Radiographic Imaging for Wall Apposition to Estimate Neurologic Complications after Flow Diverter Treatment.AJNR. American journal of neuroradiology · 2025Article
- Accurate full-scale patient-specific Circle of Willis models including aneurysms: A novel manufacturing approach.PloS one · 2025Article
- In vitro and in silico assessment of flow modulation after deploying the Contour Neurovascular System in intracranial aneurysm models.Journal of neurointerventional surgery · 2024Article
- Fluid dynamics in intracranial aneurysms treated with flow-diverting stents: effect of multiple geometrical parameters.Journal of fluid mechanics · 2023Article
- Fabrication of Compliant and Transparent Hollow Cerebral Vascular Phantoms for In Vitro Studies Using 3D Printing and Spin-Dip Coating.Materials (Basel, Switzerland) · 2022Article
- A multicenter hemodynamics-based nomogram predicting incomplete occlusion of intracranial aneurysms treated with pipeline embolization device.Frontiers in neurologyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFlow-diverting stents are increasingly used for the minimally-invasive treatment of intracranial aneurysms. However, a correct positioning of such devices can be challenging due to varying vessel diameters as well as the complex anatomy of the neurovasculature. As a consequence, unsuccessful treatment outcomes are increasingly reported requiring an improvement of the understanding of stent-induced flow modification.
methodsTo evaluate the effect of different degrees of flow diverter stent malposition on intra-aneurysmal hemodynamic changes, a controlled hemodynamic configuration was created using an idealized intracranial aneurysms model. Afterwards, four different treatment scenarios were reproduced comprising of 1) the ideal treatment, 2) an insufficient wall apposition in the region of the ostium, 3) a distorted device migrating into the aneurysm sac and 4) an inaccurately deployed stent due to wrong release location. For the assessment of the individual flow modifications, high-resolution stereoscopic particle image velocimetry (PIV) measurements were carried out.
resultsThe analysis of the precise in-vitro PIV measurements reveals that in all cases a considerable reduction of the cycle-averaged and peak-systolic velocity was obtained. Compared to the untreated aneurysm configuration, the flow reduction ranged from 63% (scenario 4) up to 89% (scenario 3). The ideal treatment reached a reduction of 78%, which is known to be sufficient for a successful therapy. However, inaccurate device positioning leads to increased oscillating flow towards the lateral directions reducing the chances of sufficient thrombus formation.
conclusionsHigh-resolution in-vitro PIV measurements enable an accurate quantification of the treatment efficacy for flow-diverting devices. Furthermore, insufficient treatment outcomes can be reproduces allowing for an assessment of intra-aneurysmal hemodynamic changes.
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