Evidence map›Paper›PMID 35235553›Full record

ArticlePLoS biology2022

A common evolutionary origin reveals fundamental principles of protein insertases.

F-Nora Vögtle, Hans-Georg Koch, Chris Meisinger

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. YidC fromBiomolecules · 2023
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

F-Nora VögtleCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.
Hans-Georg KochInstitute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Chris MeisingerCIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.
University of Freiburg · DEDKFZ-ZMBH Alliance · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membrane proteins require protein machineries to insert their hydrophobic transmembrane domains (TMDs) into the lipid bilayer. A functional analysis of protein insertases in this issue of PLOS Biology reveals that the fundamental mechanism of membrane protein insertion is universally conserved.

Indexed as

Lipid BilayersMembrane ProteinsHydrophobic and Hydrophilic InteractionsLipid BilayersMembrane Proteins

Identifiers

PMID35235553
PMCPMC8890630
OpenAlexW4214833785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.