Evidence map›Paper›PMID 35235491›Full record

ArticleAnnals of clinical biochemistry2022

Faecal haemoglobin concentration in adenoma, before and after polypectomy, approaches the ideal tumour marker.

Craig Mowat, Jayne Digby, Shirley Cleary, Lynne Gray, Pooja Datt, David R Goudie, Robert Jc Steele, Judith A Strachan, Adam Humphries, Callum G Fraser

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06220149 (FIT for Post poLypectomy bLeeding Prediction), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06220149 unknown statusnot on this mapstarted 2024, after this paper: background citation

FIT for Post poLypectomy bLeeding Prediction

TypeobservationalSponsorCarol Davila University of Medicine and PharmacyRan2024 to 2025Enrolled200ConditionsPolyp Colorectal, BleedingArmsFIT (fecal immunochemical test)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Craig MowatDepartment of Gastroenterology, 1251Ninewells Hospital and Medical School, Dundee, UK.
Jayne DigbyCentre for Research Into Cancer Prevention and Screening, 85326University of Dundee School of Medicine, Dundee, UK.ORCID 0000-0003-1775-8734
Shirley ClearyDepartment of Gastroenterology, 1251Ninewells Hospital and Medical School, Dundee, UK.
Lynne GrayDepartment of Surgery, 1251Ninewells Hospital and Medical School, Dundee, UK.
Pooja DattDepartment of Gastroenterology, St Mark's Hospital and Academic Institute, London, UK.
David R GoudieDepartment of Genetics, 1251Ninewells Hospital and Medical School, Dundee, UK.
Robert Jc SteeleCentre for Research Into Cancer Prevention and Screening, 85326University of Dundee School of Medicine, Dundee, UK.
Judith A StrachanDepartment of Blood Sciences and Scottish Bowel Screening Laboratory, 1251Ninewells Hospital and Medical School, Dundee, UK.
Adam HumphriesDepartment of Gastroenterology, St Mark's Hospital and Academic Institute, London, UK.
Callum G FraserCentre for Research Into Cancer Prevention and Screening, 85326University of Dundee School of Medicine, Dundee, UK.ORCID 0000-0002-1333-7994
Ninewells Hospital · GBUniversity of Dundee · GBSt Mark's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolypectomy may be performed at colonoscopy and then subsequent surveillance undertaken. It is thought that faecal haemoglobin concentration (f-Hb), estimated by quantitative faecal immunochemical tests (FIT), might be a useful tumour marker.

methodsConsecutive patients enrolled in colonoscopy surveillance were approached at two hospitals. A specimen for FIT was provided before colonoscopy and, ideally after 3 weeks, a second FIT sample from those who had polypectomy. A single FIT system (OC-Sensor io, Eiken Chemical Co., Ltd) was used to generate f-Hb.

results1103 Patients were invited; 643 returned a FIT device (uptake: 58.3%). Four patients had known inflammatory bowel disease (IBD) and were excluded, leaving 639 (57.9%) with an age range of 25-90 years (median 64 years), 54.6% male. Of 593 patients who had a f-Hb result and completed colonoscopy, advanced neoplasia was found in 41 (6.9%); four colorectal cancer (CRC): 0.7% and 37 advanced adenoma (AA): 6.3%, and a further 127 (21.4%) had non-advanced adenoma (NAA). The median f-Hb was significantly greater in AA as compared to NAA; 6.0 versus 1.0 μg Hb/g faeces,

conclusionsQuantitative FIT could provide a good tumour marker in post-polypectomy surveillance, reduce colonoscopy requirements and minimise potential risk to patients.

Indexed as

AdenomaColorectal NeoplasmsAdultAgedAged, 80 and overBiomarkers, TumorEarly Detection of CancerFecesFemaleHemoglobinsHumansMaleMiddle AgedOccult BloodBiomarkers, TumorHemoglobinsAdenomacolorectal cancerfaecal haemoglobinfaecal immunochemical testpolypectomysurveillance

Identifiers

PMID35235491
PMCPMC9280698
OpenAlexW4214880947

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.